Ningbo Women and Children's Hospital, China.
J Atten Disord. 2020 Oct;24(12):1637-1647. doi: 10.1177/1087054717696766. Epub 2017 Mar 8.
Findings on maternal smoking during pregnancy and ADHD risk in children are inconsistent. A meta-analysis was performed to summarize effects of exposure to maternal smoking during pregnancy on ADHD risk in children. We conducted a systematic literature search to select articles up to June 2016. Only prospective cohort studies were included. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated. Pooled RR estimates based on 12 cohort studies including 17,304 pregnant women suggested that maternal smoking during pregnancy was associated with an increased risk of ADHD (pooled RR = 1.58, 95% CI = [1.33, 1.88]). Results from this study indicate that maternal smoking during pregnancy is related to an increased risk of ADHD in children. There is an urgent need to increase maternal awareness of smoking risk and quitting smoking to mitigate the ADHD risk in children.
关于孕期母亲吸烟与儿童注意缺陷多动障碍（ADHD）风险的关系，研究结果并不一致。本研究旨在对孕期母亲吸烟与儿童 ADHD 风险的相关关系进行汇总分析。
我们对截至 2016 年 6 月的相关文献进行了系统性检索，仅纳入前瞻性队列研究。采用汇总相对危险度（RR）及其 95%置信区间（CI）进行分析。基于 12 项包含 17304 名孕妇的队列研究的汇总 RR 估计值提示，孕期母亲吸烟与儿童 ADHD 风险增加相关（汇总 RR=1.58，95%CI=[1.33, 1.88]）。
本研究结果表明，孕期母亲吸烟与儿童 ADHD 风险增加相关。有必要提高孕妇对吸烟风险的认识并鼓励其戒烟，以降低儿童 ADHD 的发生风险。
