Huggins Alison B, Kim Charles, Rabinowitz Michael P
a Wills Eye Hospital, Thomas Jefferson University Hospital , Philadelphia , PA , USA.
b The Oculoplastic and Orbital Surgery Department of Wills Eye Hospital , Thomas Jefferson University Hospital , Philadelphia , PA , USA.
Orbit. 2018 Apr;37(2):102-104. doi: 10.1080/01676830.2017.1383460. Epub 2017 Oct 17.
This is a case description of a single male patient found to have T-cell-mediated inflammation and lymphoproliferation of the orbit. Chronic T-cell-mediated inflammatory disease can pose a diagnostic challenge particularly in its differentiation from a neoplastic process. The histopathology in this case demonstrated features of both lupus erythematosus panniculitis and features of orbital T-cell lymphoma. While both are rare, lupus erythematosus panniculitis of the orbit is even more exceptional; this patient's indolent, chronic relapsing course distinguished itself from the typical aggression of orbital T-cell lymphoma. We believe this rare case may actually represent an example of a newly described disease spectrum that incorporates lupus erythematosus panniculitis as well as subcutaneous panniculitis-like T-cell lymphoma.
这是一例男性患者的病例描述，该患者被发现存在眼眶的T细胞介导的炎症和淋巴细胞增殖。慢性T细胞介导的炎症性疾病可能带来诊断挑战，尤其是在与肿瘤性病变相鉴别时。该病例的组织病理学表现既有红斑狼疮性脂膜炎的特征，又有眼眶T细胞淋巴瘤的特征。虽然两者都很罕见，但眼眶红斑狼疮性脂膜炎更为特殊；该患者病程进展缓慢、呈慢性复发，有别于眼眶T细胞淋巴瘤典型的侵袭性。我们认为，这一罕见病例可能实际上代表了一种新描述的疾病谱的实例，该疾病谱包含红斑狼疮性脂膜炎以及皮下脂膜炎样T细胞淋巴瘤。
