血浆细胞因子和微生物易位生物标志物与免疫重建炎症综合征的关联。
Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome.
作者信息
George Varghese, Harrison Linda, Roach Margaret, Li Xiao-Dong, Tierney Camlin, Fischl Margaret A, Aberg Judith, Tebas Pablo, Asmuth David M, Pollard Richard B, Godfrey Catherine, Pahwa Savita
机构信息
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Florida.
Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public, Boston, Massachusetts.
出版信息
J Infect Dis. 2017 Nov 27;216(9):1159-1163. doi: 10.1093/infdis/jix460.
Abstract
A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.
摘要
在一项一线人类免疫缺陷病毒治疗临床试验的参与者中进行了一项巢式病例队列研究，以调查炎症和微生物易位的血浆生物标志物与免疫重建炎症综合征（IRIS）的关联。1452名基线CD4细胞计数<350个/μL的参与者中有51人发生了IRIS。分析了51例IRIS病例的血浆，包括6例根据入组前CD4细胞计数≤200个/μL分层的病例，并与94名非IRIS对照进行比较。在基线时，CXCL10、脂多糖、可溶性CD14、16S核糖体DNA和干扰素-α2与IRIS的更高风险相关。通过持续单核细胞活化和微生物易位引起的全身炎症似乎在IRIS发病机制中很重要。
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