Department of Population and Public Health Sciences, Boonshoft School of Medicine, Wright State University, 3123 Research Blvd, Suite #200, Dayton, OH 45420, USA.
The Pediatric Lipid Clinic, Dayton's Children Hospital, One Children's Plaza, Dayton, OH 45404, USA.
Environ Res. 2018 Jan;160:314-321. doi: 10.1016/j.envres.2017.10.014. Epub 2017 Oct 15.
Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children.
In a cross sectional pilot study, 48 obese children aged 8-12 years were enrolled from Dayton's Children Hospital, Ohio. Anthropometric, clinical and biochemical assessments of serum were completed. Serum PFASs were measured by UPLC-ESI-MS/MS. In a subset of 23 children, bone health parameters were measured using calcaneal quantitative ultrasound (QUS).
While PFASs exposure was associated with a consistent negative relationship with bone health parameters, among four PFASs tested, only PFNA showed a significant negative relationship with bone parameter (β [95% CI], = - 72.7 [- 126.0, - 19.6], p = .010). PFNA was also associated with raised systolic blood pressure (p = .008), low density lipoprotein cholesterol (LDL-C; p < .001), and total cholesterol (TC; p = .014). In addition, both PFOA and PFOS predicted elevation in LDL-C, and PFOA predicted increased TC, as well. In this analysis, PFASs were not strongly related to thyroid hormones, 25-hydroxy vitamin D, liver enzymes, or glucose homeostasis.
PFASs exposure in obese children may play a role in adverse skeletal and cardiovascular risk profiles.
全氟烷基物质（PFAS），包括全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟己烷磺酸（PFHxS）和全氟壬酸（PFNA），与成年人的骨骼和代谢变化有关。然而，PFAS 对儿童骨骼健康的影响研究较少。鉴于它们作为内分泌干扰物的作用，我们研究了四种 PFAS 与儿童骨骼健康的关系。
在一项横断面试点研究中，从俄亥俄州代顿儿童医院招募了 48 名 8-12 岁的肥胖儿童。完成了人体测量、临床和血清生化评估。采用 UPLC-ESI-MS/MS 法测定血清 PFASs。在 23 名儿童的亚组中，使用跟骨定量超声（QUS）测量骨骼健康参数。
虽然 PFASs 暴露与骨骼健康参数呈一致的负相关关系，但在所测试的四种 PFAS 中，只有 PFNA 与骨骼参数呈显著负相关（β[95%CI]，=-72.7[-126.0，-19.6]，p=0.010）。PFNA 还与收缩压升高（p=0.008）、低密度脂蛋白胆固醇（LDL-C；p<0.001）和总胆固醇（TC；p=0.014）降低有关。此外，PFOA 和 PFOS 均预测 LDL-C 升高，而 PFOA 还预测 TC 升高。在这项分析中，PFASs 与甲状腺激素、25-羟维生素 D、肝酶或葡萄糖稳态没有密切关系。
肥胖儿童的 PFASs 暴露可能在不良骨骼和心血管风险方面发挥作用。
