The First Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China.
The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Endocrinol (Lausanne). 2022 Oct 5;13:980608. doi: 10.3389/fendo.2022.980608. eCollection 2022.
Reports on the association of perfluoroalkyl substances (PFASs) exposure with adolescent bone health are scarce, and studies have primarily targeted maternal serum.
We evaluated the relationship between autologous serum perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) levels and bone mineral density (BMD) in adolescents.
We analyzed data from 1228 adolescents aged 12-19 years in the National Health and Nutrition Examination Survey (NHANES) 2005-2010 and used multiple regression analysis to identify the relationship between serum PFOA, PFOS, PFHxS, and PFNA concentrations and total femur, femoral neck, and lumbar spine BMD, in addition to multiple stratified subgroup analyses.
The mean age of participants was 15 years, males had higher serum PFAS concentrations than females. The results of multiple regression analysis showed that the natural log(ln)-transformed serum PFOA, PFOS, and PFNA concentrations were negatively correlated with total femur, femoral neck, and lumbar spine BMD (all p < 0.05), and ln-PFHxS was positively correlated with total femur and femoral neck BMD (all p< 0.05). In males, ln-PFOA was negatively associated with total femur and lumbar spine BMD (all p< 0.05), ln-PFOS was associated with the reduced total femur, femoral neck, and lumbar spine BMD (all p< 0.05), while ln-PFHxS and ln-PFNA were not observed to correlate with BMD at these three sites. In females, both ln-PFOA and ln-PFOS were negatively correlated with total femur and lumbar spine BMD (all p< 0.05), ln-PFHxS is associated with the increased total femur and femoral neck BMD (all p< 0.05), and ln-PFNA was negatively correlated with total femur and femoral neck BMD (all p< 0.05), most of the associations were confined to females. The associations of ln-PFOS with femoral neck BMD and ln-PFNA with total femur BMD were more significant in those who were overweight/obese and had anemia, respectively (all p for interaction < 0.05).
In this representative sample of US adolescents aged 12-19 years, certain PFAS were associated with lower bone mineral density, and most of the associations were confined to females. The negative effect of PFAS on BMD is more pronounced in those who are overweight/obese and have anemia. However, further studies are needed to confirm this finding.
关于全氟烷基物质 (PFAS) 暴露与青少年骨骼健康之间关联的报告很少，并且研究主要针对母体血清。
我们评估了青少年自体血清中全氟辛酸 (PFOA)、全氟辛烷磺酸 (PFOS)、全氟己烷磺酸 (PFHxS) 和全氟壬酸 (PFNA) 水平与骨密度 (BMD) 之间的关系。
我们分析了 2005-2010 年全国健康与营养调查 (NHANES) 中 1228 名 12-19 岁青少年的数据，并使用多元回归分析来确定血清 PFOA、PFOS、PFHxS 和 PFNA 浓度与全股骨、股骨颈和腰椎 BMD 之间的关系，此外还进行了多种分层亚组分析。
参与者的平均年龄为 15 岁，男性的血清 PFAS 浓度高于女性。多元回归分析结果表明，血清 PFOA、PFOS 和 PFNA 的自然对数 (ln)-转换浓度与全股骨、股骨颈和腰椎 BMD 呈负相关（均 p<0.05），ln-PFHxS 与全股骨和股骨颈 BMD 呈正相关（均 p<0.05）。在男性中，ln-PFOA 与全股骨和腰椎 BMD 呈负相关（均 p<0.05），ln-PFOS 与全股骨、股骨颈和腰椎 BMD 降低相关（均 p<0.05），而 ln-PFHxS 和 ln-PFNA 与这三个部位的 BMD 无关。在女性中，ln-PFOA 和 ln-PFOS 均与全股骨和腰椎 BMD 呈负相关（均 p<0.05），ln-PFHxS 与全股骨和股骨颈 BMD 升高相关（均 p<0.05），ln-PFNA 与全股骨和股骨颈 BMD 呈负相关（均 p<0.05），大多数关联仅局限于女性。ln-PFOS 与股骨颈 BMD 的关联以及 ln-PFNA 与全股骨 BMD 的关联在超重/肥胖和贫血患者中更为显著（均 p 值<0.05）。
在这项代表 12-19 岁美国青少年的样本中，某些 PFAS 与较低的骨矿物质密度有关，并且大多数关联仅局限于女性。PFAS 对 BMD 的负面影响在超重/肥胖和贫血患者中更为明显。然而，还需要进一步的研究来证实这一发现。
