男性精神病前驱期下丘脑-垂体-肾上腺轴及免疫改变的证据。
Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males.
作者信息
Karanikas Evangelos, Ntouros Evangelos, Oikonomou Dimitrios, Floros Georgios, Griveas Ioannis, Garyfallos Georgios
机构信息
School of Medicine, Rural Clinical School, The University of Queensland, Toowoomab, Australia.
Psychiatric Department, General Military Hospital of Thessaloniki, Thessaloniki, Greece.
出版信息
Psychiatry Investig. 2017 Sep;14(5):703-707. doi: 10.4306/pi.2017.14.5.703. Epub 2017 Sep 11.
We aimed to investigate the inflammatory substrate in psychosis by evaluating both the Hypothalamus-Pituitary-Adrenal axis function and immune state at prodrome. This involved the recruitment of Ultra High Risk (UHR) of Psychosis subjects, Healthy Controls (HC) and patients with established Schizophrenia (CHRON). Serum cortisol at 3 different times throughout the day was measured. The Dexamethasone Suppression Test was performed plus 12 circulating cytokines were measured. The UHR subjects presented increased IL-4 levels compared with both the HC and CHRON patients. In contrast the UHR differed only from the CHRON group regarding the endocrine parameters. In conclusion, IL-4 appears to play a key role at prodrome.
我们旨在通过评估前驱期下丘脑-垂体-肾上腺轴功能和免疫状态来研究精神病中的炎症底物。这涉及招募精神病超高风险（UHR）受试者、健康对照（HC）和已确诊精神分裂症患者（CHRON）。测量了一天中3个不同时间点的血清皮质醇。进行了地塞米松抑制试验，并检测了12种循环细胞因子。与HC和CHRON患者相比，UHR受试者的IL-4水平升高。相比之下，UHR仅在内分泌参数方面与CHRON组不同。总之，IL-4似乎在前驱期起关键作用。
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