Candidaemia in a tertiary hospital in Nigeria.

BACKGROUND

Candidaemia is a widely-studied and reviewed topic in the developed world; however, there is a dearth of information on nosocomial candidaemia in Nigeria, despite the increasing use of more invasive therapeutic modalities, immunosuppressive agents and increasing incidence of immunosuppression as a result of malignancies and HIV.

OBJECTIVES

To determine the hospital-based frequency of candidaemia in a tertiary hospital in Ibadan, Nigeria.

METHOD

This was a prospective descriptive study which included 230 immunosuppressed patients. All isolates were identified to the species level using both conventional and automated methods. Thereafter, all species isolated were tested for antifungal susceptibility using the broth microdilution method.

RESULTS

Candidaemia occurred in 12 (5.21%) of the 230 study patients, with accounting for 50% of the infections. Four patients (33.3%) presented with , one (8.3%) with and one (8.3%) with a mixed infection of and . All 12 isolates were sensitive to fluconazole (minimal inhibitory concentration < 8 mg/mL). Univariate analysis revealed that old age, multiple surgeries and long-term hospitalisation were significant contributing factors for the occurrence of candidaemia. Eleven (91.7%) of the 12 patients with candidaemia had colonisation of other sterile sites including the bladder, peritoneum and trachea. Furthermore, bivariate analysis revealed that mucositis ( = 0.019) and diarrhoea ( = 0.017) were significantly associated with an increased risk of candidaemia. The crude mortality rate of candidaemia was 91.7%.

CONCLUSION

This study highlights the significance of nosocomial candidaemia and the need for proactive laboratory investigation and clinical management of this life-threatening disease.