关键问题：接受治疗的HIV感染者中的肥胖与内脏脂肪过多
The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection.
作者信息
Lake Jordan E
机构信息
University of Texas Health Science Center at Houston, 6431 Fannin St., MSB 2.112, Houston, TX, 77030, USA.
出版信息
Curr HIV/AIDS Rep. 2017 Dec;14(6):211-219. doi: 10.1007/s11904-017-0368-6.
PURPOSE OF REVIEW
The aim of this review is to summarize knowledge of the prevalence, relevant physiology, and consequences of obesity and visceral adiposity in HIV-infected adults, including highlighting gaps in current knowledge and future research directions.
RECENT FINDINGS
Similar to the general population, obesity prevalence is increasing among HIV-infected persons, and obesity and visceral adiposity are associated with numerous metabolic and inflammatory sequelae. However, HIV- and antiretroviral therapy (ART)-specific factors may contribute to fat gain and fat quality in treated HIV infection, particularly to the development of visceral adiposity, and sex differences may exist. Obesity and visceral adiposity commonly occur in HIV-infected persons and have significant implications for morbidity and mortality. Future research should aim to better elucidate the HIV- and ART-specific contributors to obesity and visceral adiposity in treated HIV infection, with the goal of developing targeted therapies for the prevention and treatment of obesity and visceral adiposity in the modern ART era.
综述目的
本综述旨在总结关于HIV感染成人中肥胖和内脏脂肪过多的患病率、相关生理学以及后果的知识，包括突出当前知识中的空白和未来研究方向。
最新发现
与普通人群相似，HIV感染者中的肥胖患病率正在上升，肥胖和内脏脂肪过多与众多代谢和炎症后遗症相关。然而，HIV和抗逆转录病毒疗法（ART）的特异性因素可能导致接受治疗的HIV感染者脂肪增加和脂肪质量变化，特别是内脏脂肪过多的发展，并且可能存在性别差异。肥胖和内脏脂肪过多在HIV感染者中普遍存在，对发病率和死亡率有重大影响。未来研究应致力于更好地阐明在接受治疗的HIV感染中导致肥胖和内脏脂肪过多的HIV和ART特异性因素，目标是在现代ART时代开发针对肥胖和内脏脂肪过多的预防和治疗的靶向疗法。
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