Hirigo Agete Tadewos, Derbe Moges, Yilma Daniel, Astatkie Ayalew, Debebe Zelalem
School of Medical Laboratory Science, College of Medicine Health Sciences, Hawassa University, Hawassa, Ethiopia.
Center for Food Science and Nutrition, Addis Ababa University, Addis Ababa, Ethiopia.
Obes Pillars. 2025 Jun 6;15:100184. doi: 10.1016/j.obpill.2025.100184. eCollection 2025 Sep.
we aimed to evaluate the impact of lifestyle modification counselling on weight and body composition among adults with overweight or obesity receiving antiretroviral treatment (ART).
This randomized, open-label, controlled trial enrolled 126 adults aged 18-65 years, living with human immunodeficiency virus (HIV) and classified as overweight or obese. Of these, 116 participants (63 in the control group and 53 in the intervention group) completed the six-month follow-up. Weight and body composition outcomes were analyzed among those who completed the study, with comparisons made between baseline and post-intervention measurements. The effect of lifestyle modification counselling on weight and body composition was evaluated through linear mixed effects model and multiple linear regression analysis.
Over the six-month trial, participants who received lifestyle modification counselling showed significantly greater reductions in body weight (Δ = -1.4 kg, p = 0.002), visceral fat (Δ = -0.53, p = 0.006), fat mass (Δ = -2.16 kg, p < 0.001), and body fat percentage (Δ = -2.02 %, p < 0.001) compared to the control group. The intervention group experienced greater increases in fat-free mass (Δ = +0.673 kg, p = 0.068) and percentage skeletal muscle (Δ = +1.27 %, p < 0.001) compared to the control group. Additionally, lifestyle modification counselling significantly contributed to achieving at least a 3 % weight loss from baseline (β = 0.158, p = 0.048).
Lifestyle modification counselling resulted in promising and favorable changes in weight and body composition. Therefore, offering routine structured counselling interventions within ART clinics for individuals with overweight or obesity may help reduce obesity-related health risks and improve clinical outcomes (Thai Clinical Trials Registry TCTR20240905007).
我们旨在评估生活方式改善咨询对接受抗逆转录病毒治疗（ART）的超重或肥胖成年人的体重和身体成分的影响。
这项随机、开放标签、对照试验纳入了126名年龄在18 - 65岁之间、感染人类免疫缺陷病毒（HIV）且被归类为超重或肥胖的成年人。其中，116名参与者（对照组63名，干预组53名）完成了为期六个月的随访。对完成研究的参与者的体重和身体成分结果进行了分析，并对基线测量值和干预后测量值进行了比较。通过线性混合效应模型和多元线性回归分析评估生活方式改善咨询对体重和身体成分的影响。
在为期六个月的试验中，接受生活方式改善咨询的参与者与对照组相比，体重（Δ = -1.4 kg，p = 0.002）、内脏脂肪（Δ = -0.53，p = 0.006）、脂肪量（Δ = -2.16 kg，p < 0.001）和体脂百分比（Δ = -2.02%，p < 0.001）的下降幅度显著更大。与对照组相比，干预组的去脂体重（Δ = +0.673 kg，p = 0.068）和骨骼肌百分比（Δ = +1.27%，p < 0.001）增加幅度更大。此外，生活方式改善咨询对从基线至少减重3%有显著贡献（β = 0.158，p = 0.048）。
生活方式改善咨询在体重和身体成分方面带来了有前景且有利的变化。因此，在ART诊所为超重或肥胖个体提供常规结构化咨询干预可能有助于降低肥胖相关的健康风险并改善临床结局（泰国临床试验注册中心TCTR20240905007）。
