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冷冻疗法联合干扰素治疗慢性宫颈炎合并HPV感染的临床疗效

Clinical efficacy of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection.

作者信息

Su Yuehui, Zhang Mengzhen, Zhang Weiwei, Shi Huirong

机构信息

Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

出版信息

Pak J Pharm Sci. 2017 Jul;30(4(Suppl.)):1505-1508.

Abstract

This paper aims to investigate the clinical curative effect and adverse reactions of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection. 100 cases diagnosed with chronic cervicitis complicated with HPV infection from August 2014 to August 2015 in our hospital were selected and randomly divided into observation group (50 cases) and control group (50 cases). The preoperative and postoperative HPV-DNA changes were observed, and the vaginal discharge, time of decrustation and hemostasis, HPV negative conversion ratio and clinical efficacy were compared, to record the adverse reactions during treatment. After treatment, the level of RLU/CO value of the observation group was significantly lower than that of the control group (P<0.05); the vaginal discharge and time of decrustation and hemostasis of the observation group were shorter than that of the control group (P<0.05); 3 months after treatment, the HPV negative conversion ratio in the observation group was significantly higher than that in the control group; the total efficiency of the observation group was higher than that of the control group, with statistical significance (P<0.05). There were no serious adverse reactions in the two groups during the treatment. The efficiency of cervicitis complicated with HPV infection in the treatment of cryotherapy combined with interferon was more significantly. It can effectively reduce the load of HPV, promote the recovery of patients with pathological changes. Therefore, it is worth promoting.

摘要

本文旨在探讨冷冻疗法联合干扰素治疗慢性宫颈炎合并HPV感染的临床疗效及不良反应。选取2014年8月至2015年8月在我院确诊为慢性宫颈炎合并HPV感染的100例患者,随机分为观察组(50例)和对照组(50例)。观察术前、术后HPV-DNA变化,比较阴道分泌物、脱痂止血时间、HPV转阴率及临床疗效,记录治疗期间的不良反应。治疗后,观察组RLU/CO值水平明显低于对照组(P<0.05);观察组阴道分泌物及脱痂止血时间短于对照组(P<0.05);治疗3个月后,观察组HPV转阴率明显高于对照组;观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未出现严重不良反应。冷冻疗法联合干扰素治疗慢性宫颈炎合并HPV感染的疗效更显著。其可有效降低HPV负荷,促进患者病理改变恢复。因此,值得推广。

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