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A highly conserved sequence on the short arm of chromosome 7 detects multiple polymorphisms.

作者信息

Bardoni B, Guioli S, Maserati E, Maraschio P, Camerino G

机构信息

Biologia Generale e Genetica Medica, Università di Pavia, Italy.

出版信息

Hum Genet. 1988 Dec;81(1):23-5. doi: 10.1007/BF00283723.

DOI:10.1007/BF00283723
PMID:2904403
Abstract

We have isolated a human DNA fragment (laboratory acronym G98) that detects related sequences in mammals, chicken and Drosophila DNAs. This sequence has been mapped to human chromosome 7 p14-p15 by in situ hybridization. Probe G98 recognizes an insertion-deletion type polymorphism, with allelic frequencies of about 0.5, which can be detected with at least six different restriction enzymes. A second polymorphism, which can be detected in human DNA digested with TaqI, is in non-complete linkage disequilibrium with the first polymorphism. About 70% of the individuals analysed have been found to be heterozygous at this locus.

摘要

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Nature. 1981 Oct 1;293(5831):374-6. doi: 10.1038/293374a0.
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Regional localization on the human X chromosome and polymorphism of the coagulation factor IX gene (hemophilia B locus).
凝血因子IX基因（B型血友病位点）在人类X染色体上的区域定位及多态性
Proc Natl Acad Sci U S A. 1984 Jan;81(2):498-502. doi: 10.1073/pnas.81.2.498.
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A closely linked genetic marker for cystic fibrosis.一种与囊性纤维化紧密连锁的遗传标记。
Nature. 1985;318(6044):382-4. doi: 10.1038/318382a0.
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Genetic mapping of the human X chromosome: linkage analysis of the q26-q28 region that includes the fragile X locus and isolation of expressed sequences.
Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:195-203. doi: 10.1101/sqb.1986.051.01.024.
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Localization of cystic fibrosis locus to human chromosome 7cen-q22.囊性纤维化基因座定位于人类染色体7cen-q22。
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A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7.
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8
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