Barker D, Green P, Knowlton R, Schumm J, Lander E, Oliphant A, Willard H, Akots G, Brown V, Gravius T
Whitehead Institute, Cambridge Center, MA 02142.
Proc Natl Acad Sci U S A. 1987 Nov;84(22):8006-10. doi: 10.1073/pnas.84.22.8006.
High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have constructed a genetic map of chromosome 7 with 63 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed multilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.
人类各条染色体的高密度遗传图谱将有助于准确确定疾病相关基因的位置，并为构建物理图谱提供有用的标记。我们利用来自23个三代家系的分离数据和最近开发的多位点连锁分析技术，构建了包含63个多态性DNA标记的7号染色体遗传图谱。该图谱在女性中跨度为250厘摩，在男性中跨度为170厘摩，大部分差异集中在几个区间。这些标记的密度和信息含量使得对于该染色体上任何一个有20个已知减数分裂相的疾病基因，检测到连锁的可能性很高。
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