• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex.

作者信息

Matthews D A, Alden R A, Bolin J T, Filman D J, Freer S T, Hamlin R, Hol W G, Kisliuk R L, Pastore E J, Plante L T, Xuong N, Kraut J

出版信息

J Biol Chem. 1978 Oct 10;253(19):6946-54.

PMID:29045
Abstract
摘要

相似文献

1
Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex.干酪乳杆菌的二氢叶酸还原酶。甲氨蝶呤.NADPH复合物酶的X射线结构。
J Biol Chem. 1978 Oct 10;253(19):6946-54.
2
Interpretation of nuclear magnetic resonance spectra for Lactobacillus casei dihydrofolate reductase based on the X-ray structure of the enzyme-methotrexate-NADPH complex.基于干酪乳杆菌二氢叶酸还原酶-甲氨蝶呤-NADPH复合物的X射线结构对其核磁共振谱的解读
Biochemistry. 1979 Apr 17;18(8):1602-10. doi: 10.1021/bi00575a035.
3
Dihydrofolate reductase from Lactobacillus casei. Stereochemistry of NADPH binding.干酪乳杆菌的二氢叶酸还原酶。NADPH结合的立体化学
J Biol Chem. 1979 May 25;254(10):4144-51.
4
Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.大肠杆菌和干酪乳杆菌二氢叶酸还原酶的晶体结构在1.7埃分辨率下的精修。I. 甲氨蝶呤的一般特征和结合情况
J Biol Chem. 1982 Nov 25;257(22):13650-62.
5
NMR-based solution structure of the complex of Lactobacillus casei dihydrofolate reductase with trimethoprim and NADPH.基于核磁共振的干酪乳杆菌二氢叶酸还原酶与甲氧苄啶和烟酰胺腺嘌呤二核苷酸磷酸复合物的溶液结构
J Biomol NMR. 2002 Sep;24(1):67-70. doi: 10.1023/a:1020659713373.
6
Interaction of the carboxamide of NADPH, with Lactobacillus casei dihydrofolate reductase.烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的羧酰胺与干酪乳杆菌二氢叶酸还原酶的相互作用。
Arch Biochem Biophys. 1982 Jan;213(1):338-40. doi: 10.1016/0003-9861(82)90471-4.
7
Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. II. Environment of bound NADPH and implications for catalysis.大肠杆菌和干酪乳杆菌二氢叶酸还原酶在1.7埃分辨率下的晶体结构。II. 结合的NADPH的环境及其对催化作用的影响。
J Biol Chem. 1982 Nov 25;257(22):13663-72.
8
Dihydrofolate reductase. 1H resonance assignments and coenzyme-induced conformational changes.
J Mol Biol. 1986 Mar 5;188(1):81-97. doi: 10.1016/0022-2836(86)90483-3.
9
31P-NMR studies of NADPH, NADP+ and the complex of NADPH and methotrexate with Lactobacillus casei dihydrofolate reductase in the solid state.固态下用31P核磁共振研究NADPH、NADP+以及NADPH与甲氨蝶呤和干酪乳杆菌二氢叶酸还原酶复合物。
Eur J Biochem. 1994 Nov 15;226(1):211-8. doi: 10.1111/j.1432-1033.1994.tb20043.x.
10
TPNH-dependent binding of amethopterin by dihydrofolate reductase from Lactobacillus casei.干酪乳杆菌二氢叶酸还原酶对氨甲蝶呤的三磷酸吡啶核苷酸依赖型结合
Arch Biochem Biophys. 1972 Sep;152(1):429-31. doi: 10.1016/0003-9861(72)90234-2.

引用本文的文献

1
A general assay platform to study protein pharmacology using ligand-dependent structural dynamics.一种利用配体依赖性结构动力学研究蛋白质药理学的通用检测平台。
Nat Commun. 2025 May 10;16(1):4342. doi: 10.1038/s41467-025-59658-6.
2
The impact of the human gut microbiome on the treatment of autoimmune disease.人类肠道微生物组对自身免疫性疾病治疗的影响。
Immunol Rev. 2024 Aug;325(1):107-130. doi: 10.1111/imr.13358. Epub 2024 Jun 12.
3
Albumin-Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells.
进入恶性胶质瘤细胞后经历细胞内再活化的白蛋白 - 甲氨蝶呤前药类似物。
Pharmaceutics. 2021 Dec 28;14(1):71. doi: 10.3390/pharmaceutics14010071.
4
Design and in vitro validation of multivalent dendrimer methotrexates as a folate-targeting anticancer therapeutic.设计并体外验证多价树状物甲氨蝶呤作为叶酸靶向抗癌治疗药物。
Curr Pharm Des. 2013;19(37):6594-605. doi: 10.2174/1381612811319370004.
5
Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic.多价树状物-甲氨蝶呤作为一种叶酸受体靶向的癌症治疗药物。
Mol Pharm. 2012 Sep 4;9(9):2669-2676. doi: 10.1021/mp3002232. Epub 2012 Aug 7.
6
Selectivity analysis of 5-(arylthio)-2,4-diaminoquinazolines as inhibitors of Candida albicans dihydrofolate reductase by molecular dynamics simulations.通过分子动力学模拟对5-（芳硫基）-2,4-二氨基喹唑啉作为白色念珠菌二氢叶酸还原酶抑制剂的选择性分析。
J Comput Aided Mol Des. 2000 Jul;14(5):495-506. doi: 10.1023/a:1008189724803.
7
Mutations in the dihydrofolate reductase gene of trimethoprim-resistant isolates of Streptococcus pneumoniae.耐甲氧苄啶肺炎链球菌分离株二氢叶酸还原酶基因的突变
Antimicrob Agents Chemother. 1997 Nov;41(11):2406-13. doi: 10.1128/AAC.41.11.2406.
8
A molecular model of the folate binding site of Pneumocystis carinii dihydrofolate reductase.卡氏肺孢子虫二氢叶酸还原酶叶酸结合位点的分子模型。
J Comput Aided Mol Des. 1994 Apr;8(2):113-22. doi: 10.1007/BF00119862.
9
Flexibases: a way to enhance the use of molecular docking methods.柔性底座：一种增强分子对接方法应用的途径。
J Comput Aided Mol Des. 1994 Oct;8(5):565-82. doi: 10.1007/BF00123666.
10
The effects of modification with N-bromosuccinimide on the binding of ligands to dihydrofolate reductase.N-溴代琥珀酰亚胺修饰对配体与二氢叶酸还原酶结合的影响。
Biochem J. 1980 May 1;187(2):501-6. doi: 10.1042/bj1870501.