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嗜酸性粒细胞与嗜酸性粒细胞相关疾病:最新研究进展。

Eosinophils and eosinophil-associated diseases: An update.

机构信息

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.

出版信息

J Allergy Clin Immunol. 2018 Feb;141(2):505-517. doi: 10.1016/j.jaci.2017.09.022. Epub 2017 Oct 16.

DOI:10.1016/j.jaci.2017.09.022
PMID:29045815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5803328/
Abstract

The goal of this series is to offer a survey of the latest literature for clinicians and scientists alike, providing a list of important recent advances relevant to the broad field of allergy and immunology. This particular assignment was to cover the topic of eosinophils. In an attempt to highlight major ideas, themes, trends, and advances relevant to basic and clinical aspects of eosinophil biology, a search of articles published since 2015 in the Journal of Allergy and Clinical Immunology and other high-impact journals was performed. Articles were then reviewed and organized, and then key findings were summarized. Given space limitations, many outstanding articles could not be included, but the hope is that what follows provides a succinct overview of recently published work that has significantly added to our knowledge of eosinophils and eosinophil-associated diseases.

摘要

本系列的目标是为临床医生和科学家提供最新文献综述,列出与过敏和免疫学广泛领域相关的重要最新进展。本次任务是涵盖嗜酸性粒细胞这一主题。为了突出与嗜酸性粒细胞生物学基础和临床方面相关的主要观点、主题、趋势和进展,我们对自 2015 年以来在《过敏与临床免疫学杂志》和其他高影响力期刊上发表的文章进行了检索。然后对文章进行了回顾和整理,并总结了主要发现。由于篇幅限制,许多优秀的文章无法纳入,但希望以下内容能简要概述最近发表的工作,这些工作显著增加了我们对嗜酸性粒细胞和嗜酸性粒细胞相关疾病的认识。

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Eosinophils and eosinophil-associated diseases: An update.嗜酸性粒细胞与嗜酸性粒细胞相关疾病:最新研究进展。
J Allergy Clin Immunol. 2018 Feb;141(2):505-517. doi: 10.1016/j.jaci.2017.09.022. Epub 2017 Oct 16.
2
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Eosinophil Development, Disease Involvement, and Therapeutic Suppression.嗜酸性粒细胞的发育、疾病参与和治疗抑制。
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Pak J Med Sci. 2025 Jul;41(7):2087-2091. doi: 10.12669/pjms.41.7.12064.
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Myeloid cells in chronic liver inflammation.慢性肝脏炎症中的髓样细胞。
Cell Mol Immunol. 2025 Jul 28. doi: 10.1038/s41423-025-01324-4.
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Association between eosinophil number and overweight status: a nonlinear, bidirectional study.嗜酸性粒细胞数量与超重状态之间的关联:一项非线性双向研究。

本文引用的文献

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Efficacy of a 4-Food Elimination Diet for Children With Eosinophilic Esophagitis.四食物剔除饮食疗法对嗜酸细胞性食管炎患儿的疗效。
Clin Gastroenterol Hepatol. 2017 Nov;15(11):1698-1707.e7. doi: 10.1016/j.cgh.2017.05.048. Epub 2017 Jun 8.
2
Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial.贝那鲁肽治疗轻中度持续性哮喘患者(BISE):一项随机、双盲、安慰剂对照、3 期临床试验。
Lancet Respir Med. 2017 Jul;5(7):568-576. doi: 10.1016/S2213-2600(17)30190-X. Epub 2017 May 22.
3
Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma.
Lipids Health Dis. 2025 May 10;24(1):172. doi: 10.1186/s12944-025-02581-y.
4
Deep insight into cytokine storm: from pathogenesis to treatment.深入洞察细胞因子风暴:从发病机制到治疗。
Signal Transduct Target Ther. 2025 Apr 16;10(1):112. doi: 10.1038/s41392-025-02178-y.
5
Inflammation-fibrosis interplay in inflammatory bowel disease: mechanisms, progression, and therapeutic strategies.炎症性肠病中炎症与纤维化的相互作用:机制、进展及治疗策略
Front Pharmacol. 2025 Feb 28;16:1530797. doi: 10.3389/fphar.2025.1530797. eCollection 2025.
6
Antiviral roles of eosinophils in asthma and respiratory viral infection.嗜酸性粒细胞在哮喘和呼吸道病毒感染中的抗病毒作用。
Front Allergy. 2025 Feb 28;6:1548338. doi: 10.3389/falgy.2025.1548338. eCollection 2025.
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Analysis of Sanfeng Tongqiao Diwan in treating upper airway cough syndrome: issues & insights.三拗通窍滴丸治疗上气道咳嗽综合征的分析:问题与见解
J Thorac Dis. 2025 Jan 24;17(1):514-515. doi: 10.21037/jtd-2024-1938. Epub 2025 Jan 22.
8
Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma.血清和尿液嗜酸性粒细胞衍生神经毒素(EDN)水平可预测重度哮喘的生物学反应。
World Allergy Organ J. 2025 Jan 9;18(1):100990. doi: 10.1016/j.waojou.2024.100990. eCollection 2025 Jan.
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The Immunosuppressive Functions of Eosinophils Are Compromised in Patients With Allergic Rhinitis, Particularly Concerning Rab27a Expression.嗜酸性粒细胞的免疫抑制功能在变应性鼻炎患者中受损,尤其是在Rab27a表达方面。
Immun Inflamm Dis. 2024 Dec;12(12):e70091. doi: 10.1002/iid3.70091.
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Lancet. 2017 Jun 10;389(10086):2287-2303. doi: 10.1016/S0140-6736(17)31191-1. Epub 2017 May 4.
7
Biologics and biomarkers for asthma, urticaria, and nasal polyposis.哮喘、荨麻疹和鼻息肉的生物制剂和生物标志物。
J Allergy Clin Immunol. 2017 May;139(5):1411-1421. doi: 10.1016/j.jaci.2017.03.006.
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Asthma Control and Sputum Eosinophils: A Longitudinal Study in Daily Practice.哮喘控制与痰嗜酸性粒细胞:日常实践中的纵向研究。
J Allergy Clin Immunol Pract. 2017 Sep-Oct;5(5):1335-1343.e5. doi: 10.1016/j.jaip.2017.01.026. Epub 2017 Apr 25.
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Blood eosinophils predict therapeutic effects of a GATA3-specific DNAzyme in asthma patients.血液嗜酸性粒细胞可预测GATA3特异性脱氧核酶对哮喘患者的治疗效果。
J Allergy Clin Immunol. 2017 Aug;140(2):625-628.e5. doi: 10.1016/j.jaci.2017.02.024. Epub 2017 Mar 22.
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