Department of Neuroscience and Physiology, NYU Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016, USA.
Department of Neuroscience and Physiology, NYU Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016, USA.
Cell Rep. 2017 Oct 17;21(3):721-731. doi: 10.1016/j.celrep.2017.09.075.
During embryogenesis, neural progenitors in the ganglionic eminences give rise to diverse GABAergic interneuron subtypes that populate all forebrain regions. The extent to which these cells are genetically predefined or determined by postmigratory environmental cues remains unknown. To address this question, we performed homo- and heterotopic transplantation of early postnatal MGE-derived cortical and hippocampal interneurons. Grafted cells migrated, and displayed neurochemical, electrophysiological, morphological, and neurochemical profiles similar to endogenous interneurons. Our results indicate that the host environment regulates the proportion of interneuron classes in the brain region. However, some specific interneuron subtypes retain characteristics representative of their donor brain regions.
在胚胎发生过程中，神经节隆起中的神经祖细胞产生了多种 GABA 能中间神经元亚型，这些亚型分布在所有前脑区域。这些细胞在多大程度上是由遗传预先确定的，或者是由迁移后的环境线索决定的，目前还不清楚。为了解决这个问题，我们进行了同源和异源移植早期产后 MGE 衍生的皮质和海马中间神经元。移植细胞迁移，并表现出与内源性中间神经元相似的神经化学、电生理、形态和神经化学特征。我们的结果表明，宿主环境调节了脑区中间神经元类别的比例。然而，一些特定的中间神经元亚型仍然保留着其供体脑区的特征。
