一例罕见的慢性淋巴细胞白血病、多发性骨髓瘤合并心脏淀粉样变性病例。
An unusual case of chronic lymphocytic leukemia, multiple myeloma and cardiac amyloidosis.
作者信息
Liu Dongyan, Uqdah Hakim T, Gordy Alisha D
机构信息
Department of Medicine, Greater Baltimore Medical Center, Towson, MD, USA.
Department of Pathology, the Johns Hopkins Hospital, Baltimore, MD, USA.
出版信息
J Community Hosp Intern Med Perspect. 2017 Sep 19;7(4):230-233. doi: 10.1080/20009666.2017.1370940. eCollection 2017 Oct.
Light chain amyloidosis has very rarely been reported in association with chronic lymphocytic leukemia (CLL). We reported on a 76-years-old female who presented with simultaneous kappa-restricted chronic lymphocytic leukemia (CLL) and a lambda-restricted multiple myeloma with plasma cells causing AL amyloidosis involving the heart. While monoclonal immunoglobulins occasionallyproduced by CLL have previously been implicated in AL amyloidosis, there only a few cases reported of AL amyloidosis resulting from a distinct plasma cell dyscrasia that is not clonally related to the concurrent CLL.
轻链淀粉样变性与慢性淋巴细胞白血病（CLL）相关的报道极为罕见。我们报告了一名76岁女性，她同时患有κ轻链受限的慢性淋巴细胞白血病（CLL）和λ轻链受限的多发性骨髓瘤，其浆细胞导致心脏受累的AL型淀粉样变性。虽然CLL偶尔产生的单克隆免疫球蛋白以前被认为与AL型淀粉样变性有关，但仅有少数病例报道了由一种与并发CLL无克隆相关性的独特浆细胞异常增生导致的AL型淀粉样变性。
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