不对称联芳化合物：无金属和无试剂电化学偶联技术取得进展。
Unsymmetrical Biaryl Compounds: Metal- and Reagent-Free Electrochemical Couplings Are on the Advance.
机构信息
Organisch-Chemisches Institut der Universität Münster, Correns-Str. 40, 48149, Münster, Germany.
出版信息
Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15502-15503. doi: 10.1002/anie.201707804. Epub 2017 Oct 19.
It's electrifying! Electrochemical cross-coupling of aryl compounds provides a one-step approach to unsymmetrical biaryl compounds. A boron-doped diamond electrode is used as the anode to oxidise the phenolic hydroxy group to a phenoxy radical, with 1,1,1,3,3,3-hexafluoroisopropylalcohol (HFIP) and tetraalkylammonium methylsulfate used as the solvent and electrolyte. Since no reagents are required, no waste is formed from this source.
太令人兴奋了！芳基化合物的电化学交叉偶联为合成不对称联芳化合物提供了一种一步法策略。采用掺硼金刚石电极作为阳极将酚羟基氧化成苯氧自由基，以 1,1,1,3,3,3-六氟异丙醇（HFIP）和四烷基硫酸甲基铵作为溶剂和电解质。由于不需要任何试剂，因此不会产生此类来源的废物。
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