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通过 BF·OEt-介导的六烷基二锡试剂与芳基三氮烯在室温下的交叉偶联合成芳基三甲基锡。

Synthesis of Aryl Trimethylstannane via BF·OEt-Mediated Cross-Coupling of Hexaalkyl Distannane Reagent with Aryl Triazene at Room Temperature.

机构信息

Department of Medicinal Chemistry, School of Pharmacy , Xi'an Jiaotong University , Xi'an 710061 , China.

Department of Chemistry , Zhejiang Sci-Tech University , Zhejiang , Hangzhou 310018 , China.

出版信息

J Org Chem. 2019 Jan 4;84(1):463-471. doi: 10.1021/acs.joc.8b02766. Epub 2018 Dec 24.

DOI:10.1021/acs.joc.8b02766
PMID:30540911
Abstract

BF·OEt-mediated cross-coupling of (SnMe) with aryl triazene offers a new strategy for the synthesis of aryl stannane. A variety of synthetically useful aryl trimethylstannanes were produced in moderate to good yields with this metal-free approach. One-pot sequential Stille cross-coupling with different aryl bromides provides a short entry to both symmetrical and unsymmetrical biaryl compounds.

摘要

BF·OEt 介导的（SnMe）与芳基三氮烯的交叉偶联为芳基锡烷的合成提供了一种新策略。该无金属方法以中等至良好的收率得到了多种合成有用的芳基三甲基锡烷。一锅顺序 Stille 交叉偶联不同的芳基溴化物为对称和不对称联苯化合物提供了一个简短的入口。

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