Morbid Obesity Centre, Vestfold Hospital Trust, Tønsberg, Norway.
Medical Libraries, Vestfold Hospital Trust, Tønsberg, Norway.
Obes Rev. 2018 Feb;19(2):219-232. doi: 10.1111/obr.12626. Epub 2017 Oct 18.
A systematic review and meta-analysis of randomized controlled trials was conducted to examine the effects of probiotic supplementation on body weight, body mass index (BMI), fat mass and fat percentage in subjects with overweight (BMI 25-29.9 kg m ) or obesity (BMI ≥30 kg m ). MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched for studies published between 1946 and September 2016. A meta-analysis, using a random effects model, was performed to calculate the weighted mean difference between the intervention and control groups. Of 800 studies identified through the literature search, 15 were finally included. The studies comprised a total of 957 subjects (63% women), with the mean BMI being 27.6 kg m and the duration of the interventions ranging from 3 to 12 weeks. Administration of probiotics resulted in a significantly larger reduction in body weight (weighted mean difference [95% confidence interval]; -0.60 [-1.19, -0.01] kg, I = 49%), BMI (-0.27 [-0.45, -0.08] kg m , I = 57%) and fat percentage (-0.60 [-1.20, -0.01] %, I = 19%), compared with placebo; however, the effect sizes were small. The effect of probiotics on fat mass was non-significant (-0.42 [-1.08, 0.23] kg, I = 84%).
系统评价和荟萃分析的随机对照试验进行了研究益生菌补充剂对体重，体重指数（BMI），体脂肪和体脂肪率超重（BMI 25-29.9公斤米）或肥胖（BMI ≥30公斤米）。MEDLINE，EMBASE 和考克兰中央对照试验注册中心检索了 1946 年至 2016 年 9 月期间发表的研究。使用随机效应模型进行荟萃分析，以计算干预组和对照组之间的加权均数差值。通过文献检索，共确定了 800 项研究，最终有 15 项研究纳入。这些研究共纳入了 957 名受试者（63%为女性），平均 BMI 为 27.6 公斤米，干预时间从 3 周到 12 周不等。益生菌的使用可显著降低体重（加权均数差值[95%置信区间]；-0.60 [-1.19, -0.01]公斤，I = 49%），BMI（-0.27 [-0.45, -0.08]公斤米，I = 57%）和体脂肪率（-0.60 [-1.20, -0.01]%，I = 19%），与安慰剂相比；然而，效应量较小。益生菌对体脂的影响不显著（-0.42 [-1.08, 0.23]公斤，I = 84%）。
