Department of Biology, College of Science, University of Bahrain, Sakhir Campus P. O. Box 32038, Sakhir, Bahrain.
Gastroenterology and Digestive Endoscopy Unit, Centro Diagnostico Italiano, 20147 Milan, Italy.
Nutrients. 2021 Feb 19;13(2):666. doi: 10.3390/nu13020666.
The aim of this systematic review and meta-analysis is to assess the effectiveness of probiotics in inducing body weight loss in patients with overweight or obesity with related metabolic diseases. The research was carried out on PubMed and Scopus, focusing on studies reporting the effect on anthropometric measures (weight, body mass Index (BMI), waist circumference (WC), and hip circumference (HC) after administration of various probiotic strains compared to placebo. Twenty randomized controlled trials, that included 1411 patients, were considered. The meta-analyzed mean differences (MD) for random effects showed no significant decrease in body weight after probiotic supplementation (-0.26 kg [-075, 0.23], = 0.30), while a significant BMI decrease was found (-0.73 kg/m [-1.31, -0.16], = 0.01). For WC and HC, the meta-analyzed MD for random effects showed a significant decrease (WC: -0.71 cm [-1.24; -0.19], = 0.008 and HC: -0.73 cm [-1.16; -0.30], = 0.0008). The risk of bias was also evaluated considering a high risk and a low risk according to PRISMA criteria. In conclusion, the results of this meta-analysis highlight a positive trend of probiotics supplementation on the amelioration of anthropometric measures of overweight and obese patients with related metabolic diseases. However, further research is needed before recommending the use of probiotics as a therapeutic strategy for these patients. The focus of the future research should be to evaluate the efficacy of different probiotic strains, the quantities to be administered, and the duration of the intervention.
本系统评价和荟萃分析的目的是评估益生菌在诱导超重或肥胖伴相关代谢疾病患者体重减轻方面的有效性。研究在 PubMed 和 Scopus 上进行，重点关注报告各种益生菌菌株与安慰剂相比对人体测量指标（体重、体重指数（BMI）、腰围（WC）和臀围（HC）的影响的研究。共考虑了 20 项随机对照试验，纳入了 1411 名患者。随机效应荟萃分析的平均差异（MD）显示，益生菌补充后体重无显著下降（-0.26kg[-0.75,0.23]， = 0.30），而 BMI 显著下降（-0.73kg/m[-1.31,-0.16]， = 0.01）。对于 WC 和 HC，随机效应荟萃分析的 MD 显示显著下降（WC：-0.71cm[-1.24；-0.19]， = 0.008 和 HC：-0.73cm[-1.16；-0.30]， = 0.0008）。还根据 PRISMA 标准评估了高风险和低风险的偏倚风险。总之，这项荟萃分析的结果强调了益生菌补充对改善超重和肥胖伴相关代谢疾病患者人体测量指标的积极趋势。然而，在推荐将益生菌作为这些患者的治疗策略之前，还需要进一步的研究。未来研究的重点应是评估不同益生菌菌株的疗效、要给予的数量和干预的持续时间。
