奥氏膜叶茜木树皮的植物化学研究及乙酰胆碱酯酶抑制活性

Phytochemical investigation and acetylcholinesterase inhibitory activity of bark of Hymenodictyon orixense.

作者信息

Suchaichit Nattawut, Kanokmedhakul Somdej, Kanokmedhakul Kwanjai, Moosophon Panawan, Boonyarat Chantana, Plekratoke Kusawadee, Tearavarich Ruchanok, Suchaichit Natcha P

机构信息

a Faculty of Sciences and Liberal Arts, Department of Applied Chemistry , Rajamangala University of Technology Isan , Nakhon Ratchasima , Thailand.

b Natural Products Research Unit, Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.

出版信息

Nat Prod Res. 2018 Dec;32(24):2936-2939. doi: 10.1080/14786419.2017.1389930. Epub 2017 Oct 19.

DOI:10.1080/14786419.2017.1389930

PMID:29047314

Abstract

The chemical investigation of the methanol extract of Hymenodictyon orixense bark, a Thai medicinal herb, provided five compounds. Their structures were identified on the basis of 1D NMR and MS data, as well as by comparison of the data with published values, as an iridoid glycoside: loganin (1), four coumarins: scopoletin (2), scopolin (3), hymexelsin (4) and scopoletin 7-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside (5). Compounds 1-5 showed acetylcholinesterase (AChE) inhibitory activity in the range of 13.92-34.18% at a concentration of 100 μg/mL. In addition, compounds 1 and 5 are reported for the first time from this genus.

摘要

对泰国药草奥氏膜叶茜木树皮的甲醇提取物进行化学研究，得到了五种化合物。根据一维核磁共振（1D NMR）和质谱（MS）数据，并通过将数据与已发表的值进行比较，确定了它们的结构，分别为一种环烯醚萜苷：马钱苷（1），四种香豆素：东莨菪内酯（2）、七叶苷（3）、膜叶茜素（4）和东莨菪内酯7 - O - β - D - 吡喃木糖基 - (1→6) - β - D - 吡喃葡萄糖苷（5）。化合物1 - 5在浓度为100μg/mL时显示出13.92 - 34.18%的乙酰胆碱酯酶（AChE）抑制活性。此外，化合物1和5首次从该属中报道。