苦杏仁和甜杏仁的抗胆碱酯酶及神经保护活性。 （注：这里原文括号里的“L.”不太明确具体所指，可能是植物学名的一部分等，翻译时保留原样）
Anti-cholinesterase and Neuroprotective Activities of Sweet and Bitter Apricot Kernels ( L.).
作者信息
Vahedi-Mazdabadi Yasaman, Karimpour-Razkenari Elahe, Akbarzadeh Tahmineh, Lotfian Hania, Toushih Mohammad, Roshanravan Neda, Saeedi Mina, Ostadrahimi Alireza
机构信息
Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Pharm Res. 2020 Fall;19(4):216-224. doi: 10.22037/ijpr.2019.15514.13139.
Apricot ( L.) is a fruit cultivated in various parts of the world. Both sweet and bitter kernels of apricot have been used for the treatment of different diseases such as loss of memory in Iranian traditional medicine (ITM). In the present study, the inhibitory activity of sweet and bitter extracts of apricot kernels towards cholinesterase (ChE) enzymes, both acetyl and butyrylcholinesterase was examined through Ellman's method. In addition, neuroprotectivity of aqueous extracts and amygdalin were investigated against HO-induced cell death in PC12 neurons. Among them, the best acetylcholinesterase (AChE) inhibitory activity (IC = 134.93 ± 2.88 µg/mL) and neuroprotectivity (-value < 0.0001) were obtained by the aqueous extract of bitter type. It was found that all extracts showed no butyrylcholinesterase (BChE) inhibitory activity.
杏（L.）是一种在世界各地种植的水果。杏的甜杏仁和苦杏仁在伊朗传统医学中都被用于治疗不同疾病，如记忆力减退。在本研究中，通过埃尔曼法检测了杏仁甜提取物和苦提取物对胆碱酯酶（ChE）（包括乙酰胆碱酯酶和丁酰胆碱酯酶）的抑制活性。此外，还研究了水提取物和苦杏仁苷对过氧化氢诱导的PC12神经元细胞死亡的神经保护作用。其中，苦型水提取物获得了最佳的乙酰胆碱酯酶（AChE）抑制活性（IC = 134.93 ± 2.88 µg/mL）和神经保护作用（-值 < 0.0001）。结果发现，所有提取物均无丁酰胆碱酯酶（BChE）抑制活性。
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