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含硫嘌呤核苷类似物对RNA病毒复制的抑制作用:对流感病毒的选择性抗病毒活性。

Inhibitory effect of sulphur-containing purine nucleoside analogues on replication of RNA viruses: selective antiviral activity against influenza viruses.

作者信息

Yamamoto K, Hasobe M, Saneyoshi M

机构信息

Department of Virology and Rickettsiology, National Institute of Health, Tokyo, Japan.

出版信息

Acta Virol. 1988 Sep;32(5):386-92.

PMID:2904732
Abstract

Four sulphur-containing purine nucleoside analogues: 6MP, 6-thioinosine, 6-methylthioinosine and 6-ethylthioinosine, were examined for antiviral activity against some RNA viruses. All compounds extensively inhibited the replication of influenza viruses but had no inhibitory effect on other RNA viruses: Sendai, RS, vesicular stomatitis and western equine encephalitis viruses.

摘要

研究了四种含硫嘌呤核苷类似物

6-巯基嘌呤(6MP)、6-硫代肌苷、6-甲硫基肌苷和6-乙硫基肌苷对某些RNA病毒的抗病毒活性。所有化合物均能广泛抑制流感病毒的复制,但对其他RNA病毒:仙台病毒、呼吸道合胞病毒(RS)、水泡性口炎病毒和西部马脑炎病毒没有抑制作用。

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