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Dementia, parkinsonism, and motor neuron disease: neurochemical and neuropathological correlates.

作者信息

Gilbert J J, Kish S J, Chang L J, Morito C, Shannak K, Hornykiewicz O

机构信息

Department of Pathology, Victoria Hospital, London, Ontario, Canada.

出版信息

Ann Neurol. 1988 Nov;24(5):688-91. doi: 10.1002/ana.410240518.

DOI:10.1002/ana.410240518
PMID:2904794
Abstract

The neurochemical markers for the major neurotransmitter systems were measured in the brain of a patient who died with a dementia-parkinsonism-motor neuron disease (DPMN) syndrome complex. Moderate neuronal loss in the substantia nigra, spongiform changes in the frontal cortex, and moderate anterior horn cell loss throughout the spinal cord were observed. A severe nigrostriatal dopamine deficiency provides the basis for the observed parkinsonian features. The dementia is unexplained.

摘要

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