万古霉素耐药粪肠球菌高水平磷霉素耐药性。
High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium.
出版信息
Emerg Infect Dis. 2017 Nov;23(11):1902-1904. doi: 10.3201/eid2311.171130.
Abstract
Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.
摘要
在美国宾夕法尼亚州匹兹堡，通过直肠筛查从患者中获得的 890 株万古霉素耐药粪肠球菌中，有 4 株对磷霉素的 MIC 值>1024μg/ml。这些分离株在 UDP-N-乙酰葡萄糖胺烯醇丙酮酸转移酶的活性部位有一个 Cys119Asp 取代，这一取代使磷霉素 MIC 值增加了>4 倍，使该药物在生化检测中失去活性。
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