Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.
Int J Mol Sci. 2017 Oct 19;18(10):2184. doi: 10.3390/ijms18102184.
1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], the bioactive form of vitamin D, has been shown to possess significant anti-tumor potential. While most studies so far have focused on the ability of this molecule to influence the proliferation and apoptosis of cancer cells, more recent data indicate that 1,25(OH)₂D₃ also impacts energy utilization in tumor cells. In this article, we summarize and review the evidence that demonstrates the targeting of metabolic aberrations in cancers by 1,25(OH)₂D₃, and highlight potential mechanisms through which these effects may be executed. We shed light on the ability of this molecule to regulate metabolism-related tumor suppressors and oncogenes, energy- and nutrient-sensing pathways, as well as cell death and survival mechanisms such as autophagy.
1,25-二羟维生素 D₃[1,25(OH)₂D₃]，维生素 D 的生物活性形式，已被证明具有显著的抗肿瘤潜力。虽然迄今为止的大多数研究都集中在该分子影响癌细胞增殖和凋亡的能力上，但最近的数据表明，1,25(OH)₂D₃ 还会影响肿瘤细胞的能量利用。本文总结和回顾了 1,25(OH)₂D₃ 靶向癌症代谢异常的证据，并强调了可能执行这些作用的潜在机制。我们阐明了该分子调节代谢相关肿瘤抑制因子和癌基因、能量和营养感应途径以及细胞死亡和存活机制（如自噬）的能力。
