Gromadzki Bartłomiej, Wiciński Michał, Siedlecki Zygmunt, Rzepiński Łukasz, Fajkiel-Madajczyk Anna
Department of Pharmacology and Therapeutics, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-090 Bydgoszcz, Poland.
Department of Neurosurgery, Neurotraumatology and Pediatric Neurosurgery, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-094 Bydgoszcz, Poland.
Int J Mol Sci. 2025 Aug 19;26(16):7990. doi: 10.3390/ijms26167990.
Brain tumors are a significant medical problem. This study aimed to assess the potential significance of DPYSL2, 8-OHdG, and LP-PLA2 in the oncological diagnosis of patients with brain tumors who have a vitamin D deficiency. To this end, we measured the concentrations of LP-PLA2, DPYSL2, and 8-OHdG in 62 patients with different types of brain tumors who exhibited vitamin D deficiency. No significant variations were observed that would enable the differentiation of different types of intracranial tumors. However, we found a correlation between the concentrations of LP-PLA2 and DPYSL2 and tumor size (in the GBM and brain metastases groups). Additionally, we found a correlation between Lp-PLA2 and DPYSL2 levels in patients with GBM and brain metastases. In the control group, we identified correlations between 8-OHdG and Lp-PLA2, as well as between vitamin D levels and 8-OHdG. Further research is needed to fully comprehend the examined issues.
脑肿瘤是一个重大的医学问题。本研究旨在评估双氢嘧啶酶2（DPYSL2）、8-羟基脱氧鸟苷（8-OHdG）和脂蛋白磷脂酶A2（LP-PLA2）在维生素D缺乏的脑肿瘤患者肿瘤诊断中的潜在意义。为此，我们测量了62例表现出维生素D缺乏的不同类型脑肿瘤患者的LP-PLA2、DPYSL2和8-OHdG浓度。未观察到能够区分不同类型颅内肿瘤的显著差异。然而，我们发现LP-PLA2和DPYSL2的浓度与肿瘤大小之间存在相关性（在胶质母细胞瘤和脑转移瘤组中）。此外，我们发现胶质母细胞瘤和脑转移瘤患者的Lp-PLA2和DPYSL2水平之间存在相关性。在对照组中，我们确定了8-OHdG与Lp-PLA2之间以及维生素D水平与8-OHdG之间的相关性。需要进一步的研究来全面理解所研究的问题。
