State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China.
Soc Cogn Affect Neurosci. 2017 Oct 1;12(10):1565-1573. doi: 10.1093/scan/nsx085.
The hypothalamic peptide oxytocin (OT) is crucial in social adaptation and used to treat emotional and social deficits. Here, we conducted a systematic, quantitative meta-analysis of functional-MRI studies intranasally administering OT (IN-OT) to uncover neural substrates underlying the IN-OT effects and to elucidate differential IN-OT effects between healthy and clinical populations. Meta-analyses were conducted on 66 IN-OT fMRI studies, stratified by psychopathology, valence and sex. IN-OT increased bilateral amygdala, caudate head, and superior temporal activity in healthy individuals and increased dorsal anterior cingulate activity in patients. Moreover, IN-OT decreased amygdala activity in both patients and healthy individuals but did so to a greater degree in patients than healthy individuals. The OT-increased amygdala activity was only found on the negative social and affective processes, whereas the OT-decreased amygdala activity was mainly contributed by contrasts on negative-valenced processes. IN-OT increased parahippocampal activity and decreased amygdala activity during negative socio-affective processing. During positive socio-affective processes, IN-OT increased caudate head activity. This study indicates convergent neural substrates and the underlying neuropsychological mechanisms for IN-OT effects on social and affective processes. The common and different effects of IN-OT on patients and healthy individuals and the modulation of OT effects by valence have critical implications.
下丘脑肽催产素（OT）在社会适应中至关重要，用于治疗情绪和社交缺陷。在这里，我们进行了一项系统的、定量的功能磁共振成像研究荟萃分析，经鼻内给予 OT（IN-OT），以揭示 IN-OT 效应的神经基础，并阐明健康人群和临床人群之间 IN-OT 效应的差异。荟萃分析基于精神病理学、效价和性别对 66 项 IN-OT fMRI 研究进行了分层。在健康个体中，IN-OT 增加了双侧杏仁核、尾状核头部和颞上回的活动，在患者中增加了背侧前扣带回的活动。此外，IN-OT 降低了健康个体和患者的杏仁核活动，但在患者中的降低程度大于健康个体。OT 增加的杏仁核活动仅在负面的社会和情感过程中发现，而 OT 降低的杏仁核活动主要归因于负效价过程的对比。IN-OT 在进行负面的社会情感处理时增加了海马旁回的活动并降低了杏仁核的活动。在进行积极的社会情感处理时，IN-OT 增加了尾状核头部的活动。这项研究表明，IN-OT 对社会和情感过程的影响具有一致的神经基础和潜在的神经心理学机制。IN-OT 对患者和健康个体的共同和不同影响以及效价对 OT 效应的调节具有重要意义。
