Wigton Rebekah, Radua Jocham, Allen Paul, Averbeck Bruno, Meyer-Lindenberg Andreas, McGuire Philip, Shergill Sukhi S, Fusar-Poli Paolo
The Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
The Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK and Fidmag, Cibersam, Sant Boi de Llobregat, Barcelona, Spain.
J Psychiatry Neurosci. 2015 Jan;40(1):E1-22. doi: 10.1503/jpn.130289.
Oxytocin (OXT) plays a prominent role in social cognition and may have clinical applications for disorders such as autism, schizophrenia and social anxiety. The neural basis of its mechanism of action remains unclear.
We conducted a systematic literature review of placebo-controlled imaging studies using OXT as a pharmacological manipulator of brain activity.
We identified a total of 21 studies for inclusion in our review, and after applying additional selection criteria, 11 of them were included in our fMRI voxel-based meta-analysis. The results demonstrate consistent alterations in activation of brain regions, including the temporal lobes and insula, during the processing of social stimuli, with some variation dependent on sex and task. The meta-analysis revealed significant left insular hyperactivation after OXT administration, suggesting a potential modulation of neural circuits underlying emotional processing.
This quantitative review included only a limited number of studies, thus the conclusions of our analysis should be interpreted cautiously. This limited sample size precluded a more detailed exploration of potential confounding factors, such as sex or other demographic factors, that may have affected our meta-analysis.
Oxytocin has a wide range of effects over neural activity in response to social and emotional processing, which is further modulated by sex and task specificity. The magnitude of this neural activation is largest in the temporal lobes, and a meta-analysis across all tasks and both sexes showed that the left insula demonstrated the most robust activation to OXT administration.
催产素（OXT）在社会认知中发挥着重要作用，可能对自闭症、精神分裂症和社交焦虑等疾病具有临床应用价值。其作用机制的神经基础尚不清楚。
我们对使用OXT作为脑活动药理学操纵剂的安慰剂对照成像研究进行了系统的文献综述。
我们共确定了21项研究纳入综述，在应用额外的选择标准后，其中11项被纳入我们基于功能磁共振成像（fMRI）体素的荟萃分析。结果表明，在处理社会刺激过程中，包括颞叶和脑岛在内的脑区激活存在一致变化，部分变化取决于性别和任务。荟萃分析显示，给予OXT后左侧脑岛显著过度激活，提示情绪加工潜在神经回路的可能调节。
这项定量综述仅纳入了数量有限的研究，因此我们分析的结论应谨慎解释。样本量有限妨碍了对可能影响我们荟萃分析的潜在混杂因素，如性别或其他人口统计学因素进行更详细的探索。
催产素对社会和情绪加工过程中的神经活动有广泛影响，且受性别和任务特异性的进一步调节。这种神经激活程度在颞叶中最大，对所有任务和两性进行的荟萃分析表明，左侧脑岛对给予催产素的激活最为强烈。
