Li Xiang, Tong Qiaowen, Xie Dewei, Chen Zhibo, Pan Sipei, Zhang Xu, Dong Wanli
aDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province bDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University cDepartment of Neurology, Wenzhou People's Hospital, Wenzhou, Zhejiang Province, China.
Neuroreport. 2017 Dec 13;28(18):1250-1254. doi: 10.1097/WNR.0000000000000908.
Most acute central nervous system (CNS) viral infections lead to either encephalitis or meningitis. Many neurotropic viruses may cause CNS dysfunctions through various mechanisms including oxidative stress. Serum uric acid (SUA) levels, which are associated with oxidative stress and antioxidant status, are reduced in patients with various neurological disorders, including multiple sclerosis. We investigated the possible correlation between SUA levels and clinical disease status in patients with acute CNS viral infections. We measured SUA concentrations in 336 individuals, including 179 healthy individuals and 157 patients with acute CNS viral infections. We found that the patients had lower SUA levels than the healthy individuals did irrespective of sex. Effective therapy significantly increased SUA levels. The patients' SUA levels were correlated inversely with outcomes as measured with the Glasgow Outcome Scale. SUA levels may be a biomarker for predicting treatment outcomes and prognoses for patients with acute CNS viral infections with inflammatory components.
大多数急性中枢神经系统（CNS）病毒感染会导致脑炎或脑膜炎。许多嗜神经病毒可通过包括氧化应激在内的各种机制引起中枢神经系统功能障碍。血清尿酸（SUA）水平与氧化应激和抗氧化状态相关，在包括多发性硬化症在内的各种神经系统疾病患者中会降低。我们研究了急性中枢神经系统病毒感染患者的SUA水平与临床疾病状态之间的可能相关性。我们测量了336名个体的SUA浓度，其中包括179名健康个体和157名急性中枢神经系统病毒感染患者。我们发现，无论性别如何，患者的SUA水平均低于健康个体。有效的治疗显著提高了SUA水平。患者的SUA水平与用格拉斯哥预后量表测量的结果呈负相关。SUA水平可能是预测伴有炎症成分的急性中枢神经系统病毒感染患者治疗结果和预后的生物标志物。
