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门诊头颈部手术中的多模式镇痛:一项可行性和安全性研究。

Multimodal Analgesia in Outpatient Head and Neck Surgery: A Feasibility and Safety Study.

机构信息

College of Medicine, University of Nebraska Medical Center, Omaha.

Department of Head and Neck Surgical Oncology, Estabrook Cancer Center, Nebraska Methodist Hospital, Omaha.

出版信息

JAMA Otolaryngol Head Neck Surg. 2017 Dec 1;143(12):1207-1212. doi: 10.1001/jamaoto.2017.1773.

Abstract

IMPORTANCE

Perioperative analgesia strategies that rely solely on narcotics may contribute to adverse effects and concerns about opioid abuse or dependence. Multimodal analgesia protocols incorporating nonnarcotic agents may reduce the need for postoperative narcotic use.

OBJECTIVE

To evaluate the feasibility and safety of a multimodal analgesia protocol for outpatient head and neck surgical procedures and to identify the association of the multimodal analgesia protocol with postoperative pain perception scores and patient satisfaction.

DESIGN, SETTING, AND PARTICIPANTS: Retrospective evaluation of prospectively collected data on adults who underwent outpatient thyroid, parathyroid, and parotid surgery between July 2016 and February 2017 at the head and neck surgery service of a tertiary care hospital using a multimodal analgesia strategy with use of immediate preoperative acetaminophen and gabapentin, and intention to treat with a nonnarcotic postoperative outpatient analgesia strategy.

MAIN OUTCOMES AND MEASURES

Overall patient satisfaction scores, Overall Benefit of Analgesia Score (OBAS), and median resting and peak pain scores were recorded. Incidence of reliance on a narcotic-based postoperative outpatient analgesia strategy and adverse events related to altered analgesia strategy were identified.

RESULTS

Sixty-four patients (48 [75%] female; mean [SD] age, 54.6 [14.3] years) underwent outpatient thyroid, parathyroid, or parotid surgery with use of a multimodal analgesia protocol. On a 10-point rating scale, patients reported low resting pain perception scores (median, 2 [range, 0-8]) and peak pain scores (median, 4 [range, 0-9]). The OBAS assessment for composite effectiveness of analgesia indicated a favorable median score of 1 (range, 0-10; permissible range, 0-28, with lower scores better). Thirty-nine (61%) patients were able to avoid postoperative narcotic use on discharge. Fifty-six (88%) patients reported “high” or “very high” satisfaction with the multimodal analgesia strategy. No complications related to bleeding, hematoma, significant adverse events, or readmissions were observed.

CONCLUSION AND RELEVANCE

A multimodal analgesia strategy was feasible and safe in patients undergoing outpatient head and neck surgery and may reduce the need for narcotic use. It was associated with low pain perception scores, favorable OBAS, and overall satisfaction scores. The role of multimodal analgesia needs additional evaluation through comparative effectiveness assessment vs conventional pain management strategies.

摘要

重要性

仅依赖麻醉性镇痛药的围手术期镇痛策略可能会导致不良反应,并引发对阿片类药物滥用或依赖的担忧。包含非麻醉性药物的多模式镇痛方案可能会减少术后对麻醉性镇痛药的需求。

目的

评估用于门诊头颈部手术的多模式镇痛方案的可行性和安全性,并确定多模式镇痛方案与术后疼痛感知评分和患者满意度的关系。

设计、设置和参与者:回顾性评估 2016 年 7 月至 2017 年 2 月在一家三级护理医院的头颈部外科服务中接受门诊甲状腺、甲状旁腺和腮腺手术的成年人的前瞻性数据,使用多模式镇痛方案,包括术前即刻应用对乙酰氨基酚和加巴喷丁,以及采用非麻醉性术后门诊镇痛方案的意向治疗。

主要结局和测量指标

记录总体患者满意度评分、总体镇痛获益评分(OBAS)和中位数静息和峰值疼痛评分。确定依赖基于麻醉性镇痛药的术后门诊镇痛方案的发生率以及与改变镇痛方案相关的不良事件。

结果

64 例患者(48 例[75%]为女性;平均[标准差]年龄为 54.6[14.3]岁)接受了多模式镇痛方案的门诊甲状腺、甲状旁腺或腮腺手术。在 10 分制评分中,患者报告静息疼痛感知评分较低(中位数为 2[范围为 0-8])和峰值疼痛评分较低(中位数为 4[范围为 0-9])。镇痛综合效果的 OBAS 评估显示,中位评分有利,为 1(范围为 0-10;允许范围为 0-28,评分越低越好)。39 例(61%)患者在出院时能够避免使用术后麻醉性镇痛药。56 例(88%)患者报告多模式镇痛方案的满意度“高”或“非常高”。未观察到与出血、血肿、严重不良事件或再入院相关的并发症。

结论和相关性

多模式镇痛方案在接受门诊头颈部手术的患者中是可行和安全的,并且可能减少对麻醉性镇痛药的需求。它与低疼痛感知评分、有利的 OBAS 和总体满意度评分相关。多模式镇痛的作用需要通过与传统疼痛管理策略的比较效果评估来进一步评估。

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