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长链非编码RNA HOXA11-AS作为一种竞争性内源性RNA，通过吸附miR-125a-5p来调节结直肠癌肝转移中PADI2的表达。

The lncRNA HOXA11-AS functions as a competing endogenous RNA to regulate PADI2 expression by sponging miR-125a-5p in liver metastasis of colorectal cancer.

作者信息

Chen Dong, Sun Qiang, Zhang Lufei, Zhou Xiaohu, Cheng Xiaofei, Zhou Dongkai, Ye Feng, Lin Jianjiang, Wang Weilin

机构信息

Department of Colorectal Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, China.

出版信息

Oncotarget. 2017 Aug 3;8(41):70642-70652. doi: 10.18632/oncotarget.19956. eCollection 2017 Sep 19.

DOI:10.18632/oncotarget.19956
PMID:29050308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5642583/
Abstract

Several long non-coding RNAs (lncRNAs) play important roles in the regulation of liver metastasis in colorectal cancer (CRC) patients. We previously described the potential involvement of HOMEOBOX A11 (HOXA11) antisense RNA (HOXA11-AS), miR-125a-5p, and peptidyl arginine deiminase 2 (PADI2) in promoting liver metastasis in CRC patients. In the present study, we verified the significant upregulation of HOXA11-AS and PADI2, as well as the downregulation of miR-125a-5p, in CRC patients with liver metastasis. Overexpression and knockdown studies of HOXA11-AS or PADI2, as well as gain-/loss-of-function studies of miR-125a-5p, revealed a positive correlation between HOXA11-AS and PADI2 and a negative correlation with miR-125a-5p in the regulation of liver metastasis in CRC cell lines. Overall, we conclude that HOXA11-AS promotes liver metastasis in CRC by functioning as a miR-125a-5p sponge and describe a novel HOXA11-AS-miR-125a-5p-PADI2 regulatory network involved in CRC liver metastasis.

摘要

几种长链非编码RNA（lncRNA）在结直肠癌（CRC）患者肝转移的调控中发挥着重要作用。我们之前描述了同源盒A11（HOXA11）反义RNA（HOXA11-AS）、miR-125a-5p和肽基精氨酸脱亚氨酶2（PADI2）在促进CRC患者肝转移中的潜在作用。在本研究中，我们证实了HOXA11-AS和PADI2在伴有肝转移的CRC患者中显著上调，而miR-125a-5p下调。对HOXA11-AS或PADI2进行过表达和敲低研究，以及对miR-125a-5p进行功能获得/丧失研究，结果显示在CRC细胞系肝转移调控中，HOXA11-AS与PADI2呈正相关，与miR-125a-5p呈负相关。总体而言，我们得出结论，HOXA11-AS通过充当miR-125a-5p海绵促进CRC肝转移，并描述了一个参与CRC肝转移的新型HOXA11-AS-miR-125a-5p-PADI2调控网络。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/64acc9a1ae7c/oncotarget-08-70642-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/3ff8478c210a/oncotarget-08-70642-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/9d188d20d037/oncotarget-08-70642-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/38f21506cab6/oncotarget-08-70642-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/8add25496e9e/oncotarget-08-70642-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/dedd8934cf19/oncotarget-08-70642-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/64acc9a1ae7c/oncotarget-08-70642-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/3ff8478c210a/oncotarget-08-70642-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/9d188d20d037/oncotarget-08-70642-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/38f21506cab6/oncotarget-08-70642-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/8add25496e9e/oncotarget-08-70642-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/dedd8934cf19/oncotarget-08-70642-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b082/5642583/64acc9a1ae7c/oncotarget-08-70642-g006.jpg

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