Zou Haitao, Su Ruixue, Ruan Jing, Shao Hongxia, Qian Kun, Ye Jianqiang, Qin Aijian
Ministry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, P.R. China.
Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, P.R. China.
Oncotarget. 2017 Aug 7;8(41):70847-70853. doi: 10.18632/oncotarget.20003. eCollection 2017 Sep 19.
Marek's disease virus (MDV) is an α-herpesvirus that causes immune suppression and T lymphoma in chickens. Toll-like receptor 3 (TLR3) is critical for the host immune response against MDV infection. Previously, our team demonstrated that pre-treatment of TLR3 agonist poly (I:C) inhibited Marek's disease virus infection in chicken embryo fibroblasts (CEFs). However, whether TLR3 inhibits the aggravation of MDV infection is unknown. In the current study, we found that TLR3 activation in MDV-infected CEFs effectively inhibited virus spread. Using pharmacological approaches, we revealed that pro-inflammatory cytokines and interferon-β induced by TLR3 could restrict Marek's disease virus infection. This study contributes to elucidating the function and mechanism of the TLR3 pathway in host immune responses against MDV infection.
马立克氏病病毒（MDV）是一种α疱疹病毒，可导致鸡的免疫抑制和T淋巴瘤。Toll样受体3（TLR3）对宿主抵抗MDV感染的免疫反应至关重要。此前，我们团队证明，TLR3激动剂聚肌苷酸-聚胞苷酸（poly (I:C)）预处理可抑制鸡胚成纤维细胞（CEF）中的马立克氏病病毒感染。然而，TLR3是否能抑制MDV感染的加重尚不清楚。在本研究中，我们发现MDV感染的CEF中TLR3激活可有效抑制病毒传播。通过药理学方法，我们揭示了TLR3诱导的促炎细胞因子和干扰素-β可限制马立克氏病病毒感染。本研究有助于阐明TLR3途径在宿主抵抗MDV感染免疫反应中的功能和机制。
