Mori Takeshi, Nishi Wataru, Yamada Tatsuya, Motooka Yamato, Ikeda Koei, Shiraishi Kenji, Suzuki Makoto
Department of Thoracic Surgery, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan.
Interact Cardiovasc Thorac Surg. 2017 Aug 1;25(2):167-172. doi: 10.1093/icvts/ivx079.
Tumours show an increased interstitial fluid pressure, which correlates with various pathophysiological features. Moreover, interstitial fluid pressure is a prognostic factor for cervical and lung cancer. However, there have been no reports on the usefulness of measuring interstitial fluid pressure in thymic epithelial tumours. Therefore, this study aimed to examine the relationship between interstitial fluid pressure and the clinicopathological characteristics of thymic epithelial tumours. Interstitial fluid pressure was prospectively measured at the centre of the tumour using a 1-Fr Mikro-Tip sensor catheter in 44 patients with thymic epithelial tumours, 40 with thymomas and 4 with thymic carcinomas. Data from these 44 patients were analysed for correlations between interstitial fluid pressure and clinicopathological and demographic factors including sex, age, tumour size, World Health Organization histological subtypes, myasthenia gravis, capsular invasion, mediastinal pleura invasion, lung invasion, pericardium invasion, dissemination, Masaoka-Koga stage, maximal standardized uptake value and recurrence-free survival (RFS). The mean interstitial fluid pressure was 11.3 mmHg; interstitial fluid pressure was significantly correlated with maximal standardized uptake value, lung invasion, dissemination and Masaoka-Koga stage. Low interstitial fluid pressure (≤14 mmHg) showed a tendency for better RFS compared with high interstitial pressure (P = 0.053). Lung invasion, dissemination and Masaoka-Koga stage were correlated with RFS in univariable analysis; lung invasion was selected as an independent prognostic factor in multivariable analysis. On the basis of these results, interstitial fluid pressure of thymic epithelial tumours has been shown to correlate with their clinicopathological features.
肿瘤表现出间质液压力升高，这与各种病理生理特征相关。此外，间质液压力是宫颈癌和肺癌的一个预后因素。然而，关于测量胸腺上皮肿瘤中间质液压力的实用性尚无报道。因此，本研究旨在探讨间质液压力与胸腺上皮肿瘤临床病理特征之间的关系。使用1Fr Mikro-Tip传感器导管对44例胸腺上皮肿瘤患者（40例胸腺瘤和4例胸腺癌）的肿瘤中心进行前瞻性间质液压力测量。分析这44例患者的数据，以探讨间质液压力与临床病理及人口统计学因素之间的相关性，这些因素包括性别、年龄、肿瘤大小、世界卫生组织组织学亚型、重症肌无力、包膜侵犯、纵隔胸膜侵犯、肺侵犯、心包侵犯、播散、Masaoka-Koga分期、最大标准化摄取值和无复发生存期（RFS）。间质液压力的平均值为11.3 mmHg；间质液压力与最大标准化摄取值、肺侵犯、播散和Masaoka-Koga分期显著相关。与高间质压力相比，低间质压力（≤14 mmHg）显示出无复发生存期更好的趋势（P = 0.053）。在单变量分析中，肺侵犯、播散和Masaoka-Koga分期与无复发生存期相关；在多变量分析中，肺侵犯被选为独立的预后因素。基于这些结果，胸腺上皮肿瘤的间质液压力已被证明与其临床病理特征相关。
