Li Xuelong, Li Xianliang, Fang Fang, Fu Xian, Lin Hualiang, Gao Qingchun
Institute of Neuroscience, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
College for Public Health and Social Justice, Saint Louis University, Saint Louis, Missouri.
J Stroke Cerebrovasc Dis. 2017 Dec;26(12):2700-2705. doi: 10.1016/j.jstrokecerebrovasdis.2017.03.014. Epub 2017 Oct 16.
The association between metabolic syndrome (MetS) and recurrence of stroke remains unknown. We summarized the evidence by a meta-analysis of prospective cohort studies.
We searched the PubMed, EMBASE, and Google Scholar databases from their inception until July 2016 for cohort studies investigating this research question; relevant information was extracted by 2 independent investigators, and then aggregated using the random-effects meta-analysis approach.
We identified 5 studies, including 7752 stroke patients who had a history of stroke or transient ischemic attack. Compared with persons without MetS, persons with MetS have a significantly higher risk of recurrent stroke, and the pooled relative risk (RR) was 1.52 (95% confidence interval (CI): 1.17-1.97). The strength of this association is greater than individual MetS components such as elevated blood pressure (RR = 1.05, 95% CI: .72-1.52), elevated triglycerides (RR = 1.04, 95% CI: .84-1.29), low high-density lipoprotein cholesterol (RR = 1.16, 95% CI: .91-1.48), or obesity (RR = 1.12, 95% CI: .89-1.41). The risk of recurrent stroke was highest in the group with elevated glycemia (RR = 1.70, 95% CI: 1.12-2.56).
This meta-analysis suggests that MetS might be an important predictor of recurrent stroke. Among the 5 components of MetS, elevated glycemia was a stronger predictor for recurrent stroke.
代谢综合征（MetS）与中风复发之间的关联尚不清楚。我们通过对前瞻性队列研究的荟萃分析总结了相关证据。
我们检索了PubMed、EMBASE和谷歌学术数据库，从其创建至2016年7月，以查找调查此研究问题的队列研究；由2名独立研究人员提取相关信息，然后使用随机效应荟萃分析方法进行汇总。
我们确定了5项研究，包括7752名有中风或短暂性脑缺血发作病史的中风患者。与没有MetS的人相比，患有MetS的人中风复发风险显著更高，合并相对风险（RR）为1.52（95%置信区间（CI）：1.17 - 1.97）。这种关联的强度大于单个MetS组分，如血压升高（RR = 1.05，95% CI：.72 - 1.52）、甘油三酯升高（RR = 1.04，95% CI：.84 - 1.29）、高密度脂蛋白胆固醇降低（RR = 1.16，95% CI：.91 - 1.48）或肥胖（RR = 1.12，95% CI：.89 - 1.41）。血糖升高组中风复发风险最高（RR = 1.70，95% CI：1.12 - 2.56）。
这项荟萃分析表明，MetS可能是中风复发的重要预测指标。在MetS的5个组分中，血糖升高是中风复发更强的预测指标。
