Lu Xueyan, Wang Jing, Sun Huijie, Liu Dandan, Yan Xiuli, Liu Zhuo
Reproductive Medical Center, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
School of Nursing, Xi'an Siyuan University, Xi'an, China.
Front Neurol. 2024 Aug 2;15:1398907. doi: 10.3389/fneur.2024.1398907. eCollection 2024.
The prevalence of metabolic syndrome (MetS) among patients with ischemic stroke is relatively high. The visceral fat area (VFA) is a predictor of MetS. This study aimed to estimate sex-specific optimal cut-off values of VFA and MetS risk factors among patients with ischemic stroke.
A cross-sectional study including 851 patients with ischemic stroke was conducted between March 2019 and January 2020 in a tertiary hospital in the northeast of China. VFA was measured using the dual bioelectrical impedance method. Binary logistic regression analysis was used to investigate MetS risk factors, and the VFA cut-off value was assessed using receiver operating characteristic curve analysis.
The overall prevalence of MetS was 43.4%. After adjusting for potential confounders, female sex (odds ratio [OR] = 2.86, < 0.001), the presence of visceral obesity according to VFA (OR = 7.45, < 0.001), being overweight (OR = 2.75, < 0.001) or obesity (OR = 6.00, < 0.001) were associated with an increased risk of MetS. The correlation between VFA and MetS in patients with ischemic stroke was strongest with cut-off values of 104.3 cm (sensitivity 73.0%, specificity 83.1%) for men, and 94.1 cm (sensitivity 70.9%, specificity 72.9%) for women.
MetS affected approximately a half of patients with ischemic stroke. Female sex, visceral obesity, and body mass index were independent risk factors for the development of MetS. Sex-specific reference values for VFA are proposed for the prediction of incident MetS in patients with ischemic stroke.
缺血性脑卒中患者中代谢综合征（MetS）的患病率相对较高。内脏脂肪面积（VFA）是MetS的一个预测指标。本研究旨在评估缺血性脑卒中患者中VFA及MetS危险因素的性别特异性最佳截断值。
2019年3月至2020年1月在中国东北部一家三级医院对851例缺血性脑卒中患者进行了一项横断面研究。采用双能生物电阻抗法测量VFA。采用二元逻辑回归分析研究MetS危险因素，并通过受试者工作特征曲线分析评估VFA截断值。
MetS的总体患病率为43.4%。在调整潜在混杂因素后，女性（优势比[OR]=2.86，<0.001）、根据VFA判断存在内脏肥胖（OR=7.45，<0.001）、超重（OR=2.75，<0.001）或肥胖（OR=6.00，<0.001）与MetS风险增加相关。缺血性脑卒中患者中VFA与MetS之间的相关性在男性截断值为104.3 cm（敏感性73.0%，特异性83.1%）、女性截断值为94.1 cm（敏感性70.9%，特异性72.9%）时最强。
MetS影响了约一半的缺血性脑卒中患者。女性、内脏肥胖和体重指数是MetS发生的独立危险因素。提出了VFA的性别特异性参考值，用于预测缺血性脑卒中患者新发MetS。
