Heart Failure Unit, Department of Cardiology, Athens University Hospital "Attikon", National and Kapodistrian University of Athens, Athens, Greece.
Heart Fail Rev. 2018 Jan;23(1):55-61. doi: 10.1007/s10741-017-9659-7.
Neurohumoral activation is an important feature of heart failure. Recent advances in molecular biology and imaging techniques permitted a better understanding of the central role that hypothalamus plays in the modulation of dysfunctional mechanisms, as well as the occurrence of comorbidities, such as depression, in heart failure patients. This review summarizes the commonly reported neural reflexes and molecular signaling pathways at the level of the hypothalamus along with the dysfunctional mechanisms within the paraventricular nucleus and other areas of the hypothalamus in heart failure and describes some relevant therapeutic implications.
神经体液激活是心力衰竭的一个重要特征。分子生物学和成像技术的最新进展使人们更好地理解了下丘脑在调节功能障碍机制以及心力衰竭患者合并症（如抑郁症）中的核心作用。本文总结了心力衰竭时下丘脑水平常见的神经反射和分子信号通路，以及室旁核和下丘脑其他区域的功能障碍机制，并描述了一些相关的治疗意义。
