Department of Clinical Sciences, Center for Gastrointestinal Biology and Disease, College of Veterinary Medicine, NC State University, Raleigh, NC, USA.
Neurogastroenterol Motil. 2017 Nov;29(11):1-4. doi: 10.1111/nmo.13216.
Within this issue of Neurogastroenterology and Motility, an article by Pohl et al highlights new insights from a powerful porcine model of the link between early life adversity and relapsing functional gastrointestinal disorders. Early weaning stress closely mimics the early life psychosocial stressors that have been linked to adult onset gastrointestinal dysfunction. This early weaning model provides reproducible and highly translatable outcomes in young stress-challenged pigs. Due to the convincingly comparable neurological and gastroenterological anatomy and physiology between pigs and human beings, gastrointestinal stress and injury studies utilizing swine models will provide invaluable insights to improve our understanding and treatment of gastrointestinal disease in human beings. Future studies to examine mechanisms underlying this link between early life adversity and functional gastrointestinal disorders will explore the roles of gender and hypomaturity in gastrointestinal responses to stress.
本期《神经胃肠病学与动力学期刊》中，Pohl 等人的一篇文章强调了一种强大的猪模型在早期生活逆境与复发性功能性胃肠疾病之间关联的新见解。早期断奶应激非常类似于与成年期胃肠道功能障碍相关的早期生活心理社会应激源。这种早期断奶模型为处于应激挑战中的年轻猪提供了可重现且高度可转化的结果。由于猪和人类在神经和胃肠解剖学和生理学上具有令人信服的可比性，利用猪模型进行胃肠道应激和损伤研究将为我们深入理解和治疗人类胃肠道疾病提供宝贵的见解。未来研究将探索早期生活逆境与功能性胃肠疾病之间这种关联的机制，探索性别和不成熟在胃肠道对压力反应中的作用。
