Gonzalez Liara M, Moeser Adam J, Blikslager Anthony T
Department of Clinical Sciences, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina.
Department of Population Health and Pathobiology, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina.
Transl Res. 2015 Jul;166(1):12-27. doi: 10.1016/j.trsl.2015.01.004. Epub 2015 Jan 13.
There is increasing interest in nonrodent translational models for the study of human disease. The pig, in particular, serves as a useful animal model for the study of pathophysiological conditions relevant to the human intestine. This review assesses currently used porcine models of gastrointestinal physiology and disease and provides a rationale for the use of these models for future translational studies. The pig has proven its utility for the study of fundamental disease conditions such as ischemia-reperfusion injury, stress-induced intestinal dysfunction, and short bowel syndrome. Pigs have also shown great promise for the study of intestinal barrier function, surgical tissue manipulation and intervention, as well as biomaterial implantation and tissue transplantation. Advantages of pig models highlighted by these studies include the physiological similarity to human intestine and mechanisms of human disease. Emerging future directions for porcine models of human disease include the fields of transgenics and stem cell biology, with exciting implications for regenerative medicine.
人们对用于人类疾病研究的非啮齿类动物转化模型的兴趣日益浓厚。特别是猪，作为一种有用的动物模型，可用于研究与人类肠道相关的病理生理状况。本综述评估了目前使用的猪胃肠道生理学和疾病模型，并为在未来的转化研究中使用这些模型提供了理论依据。猪已证明其在研究诸如缺血再灌注损伤、应激诱导的肠道功能障碍和短肠综合征等基本疾病状况方面的效用。猪在肠道屏障功能、手术组织操作与干预以及生物材料植入和组织移植研究方面也显示出巨大潜力。这些研究突出的猪模型优点包括与人类肠道的生理相似性以及人类疾病机制。人类疾病猪模型未来的新兴方向包括转基因和干细胞生物学领域，这对再生医学具有令人兴奋的意义。
