B(CF3)3 催化的富电子芳香族和杂芳香族化合物的区域选择性氘代反应。
B(CF)-Catalyzed Regioselective Deuteration of Electron-Rich Aromatic and Heteroaromatic Compounds.
机构信息
Leibniz Institute for Catalysis at the University of Rostock , Albert-Einstein-Straße 29a, 18059 Rostock, Germany.
出版信息
Org Lett. 2017 Nov 3;19(21):5768-5771. doi: 10.1021/acs.orglett.7b02701.
Deuterium labeled compounds find widespread application in life science. Herein, the deuteration of electron-rich (hetero)aromatic compounds employing B(CF) as the catalyst and DO as the deuterium source is reported. This protocol is highly efficient, simply manipulated, and successfully applied in the deuteration of 23 substrates including natural neurotransmitter-like melatonin. It is assumed that the weakening of the O-D bond ultimately results in the formation of electrophilic D.
氘标记化合物在生命科学中有着广泛的应用。本文报道了利用 B(CF)作为催化剂和 DO 作为氘源对富电子（杂）芳族化合物进行氘代的方法。该方法具有高效、操作简单的特点，并成功应用于包括天然神经递质样褪黑素在内的 23 种底物的氘代反应。据推测，O-D 键的削弱最终导致亲电 D 的形成。
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