硼（B（CF ））催化的选择性还原和连续区域选择性氘代反应的修饰。
Modified Chemoselective Reduction and Consecutive Regioselective Deuteration Reaction Catalyzed by B(CF).
机构信息
Department of Chemistry, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea.
Department of Chemistry, Kookmin University, 77 Jeongneung-ro, Seongbuk-gu, Seoul 02707, Republic of Korea.
出版信息
J Org Chem. 2023 Feb 17;88(4):1996-2005. doi: 10.1021/acs.joc.2c02137. Epub 2023 Jan 30.
An efficient chemoselective reduction of isatin derivatives using catalyst B(CF), benzyldimethylsilane, and HO is described. Notably, a small amount of water is shown to be a highly effective reaction promoter that decreases the reaction time and temperature for the synthesis of indolin-3-ones. Moreover, using method, excellent deuterium incorporation is achieved the catalytic α-deuteration of indolin-3-ones using B(CF) and DO.
本文描述了使用催化剂 B(CF)、苄基二甲基硅烷和 HO 对色胺衍生物进行高效的选择性还原。值得注意的是，少量水被证明是一种非常有效的反应促进剂，可缩短合成吲哚啉-3-酮的反应时间和温度。此外，使用该方法，通过 B(CF) 和 DO 实现了吲哚啉-3-酮的催化 α-氘代，氘掺入率非常高。
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