对自闭症谱系障碍高风险兄弟姐妹中常见多巴胺能变异与行为问题的探索。
An exploration of common dopaminergic variants and behavior problems in siblings at high risk for autism spectrum disorder.
作者信息
Gangi Devon N, Usher Lauren V, Messinger Daniel S
机构信息
MIND Institute, University of California, Davis, UC Davis Medical Center, 2825 50(th) Street, Sacramento, CA 95817, USA.
Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Madison, WI 53705, USA.
出版信息
Infant Behav Dev. 2017 Nov;49:267-271. doi: 10.1016/j.infbeh.2017.10.002. Epub 2017 Oct 17.
Abstract
Younger siblings of children with ASD often exhibit elevated internalizing and externalizing problems. We investigated common dopaminergic variants (DRD4 and DRD2) in relation to behavior problems at 36 months. Genotypes linked to less efficient dopaminergic functioning were associated with higher internalizing problems in high-risk siblings.
摘要
患有自闭症谱系障碍（ASD）儿童的年幼兄弟姐妹往往表现出更多的内化和外化问题。我们研究了常见的多巴胺能基因变体（DRD4和DRD2）与36个月大时行为问题的关系。与多巴胺能功能效率较低相关的基因型与高危兄弟姐妹中较高的内化问题有关。
相似文献
1
An exploration of common dopaminergic variants and behavior problems in siblings at high risk for autism spectrum disorder.对自闭症谱系障碍高风险兄弟姐妹中常见多巴胺能变异与行为问题的探索。
Infant Behav Dev. 2017 Nov;49:267-271. doi: 10.1016/j.infbeh.2017.10.002. Epub 2017 Oct 17.
2
Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention.自闭症高风险兄弟姐妹中的多巴胺能变异：与发起共同注意的关联。
Autism Res. 2016 Nov;9(11):1142-1150. doi: 10.1002/aur.1623. Epub 2016 Mar 15.
3
Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients.多巴胺能多态性与高危年轻成年人和精神科住院患者边缘性人格特质之间的关联。
Behav Brain Funct. 2010 Jan 12;6:4. doi: 10.1186/1744-9081-6-4.
4
Risk Factors for Behavioral and Emotional Difficulties in Siblings of Children With Autism Spectrum Disorder.自闭症谱系障碍儿童兄弟姐妹出现行为和情绪问题的风险因素。
Am J Intellect Dev Disabil. 2016 Nov;121(6):533-549. doi: 10.1352/1944-7558-121.6.533.
5
[Effects of the D4 dopamine receptor gene variation on behavior problems at 6 years of age].[D4多巴胺受体基因变异对6岁儿童行为问题的影响]
Neuropsychopharmacol Hung. 2005 Sep;7(3):125-31.
6
Multi-informant assessment of siblings of youth with autism spectrum disorder: Parent-child discrepancies in at-risk classification.多信息源评估自闭症谱系障碍青少年的兄弟姐妹：高危分类中的亲子差异。
Res Dev Disabil. 2017 Sep;68:78-87. doi: 10.1016/j.ridd.2017.07.012. Epub 2017 Jul 22.
7
Evidence for a gene-gene interaction in predicting children's behavior problems: association of serotonin transporter short and dopamine receptor D4 long genotypes with internalizing and externalizing behaviors in typically developing 7-year-olds.预测儿童行为问题中基因-基因相互作用的证据：血清素转运体短型和多巴胺受体D4长型基因型与正常发育的7岁儿童内化和外化行为的关联。
Dev Psychopathol. 2007 Fall;19(4):1105-16. doi: 10.1017/S0954579407000569.
8
The psychophysiological impact of childhood autism spectrum disorder on siblings.儿童自闭症谱系障碍对兄弟姐妹的心理生理影响。
Res Dev Disabil. 2016 Feb-Mar;49-50:226-34. doi: 10.1016/j.ridd.2015.11.023. Epub 2015 Dec 23.
9
Dopaminergic system genes in childhood aggression: possible role for DRD2.多巴胺能系统基因与儿童期攻击行为：DRD2 可能的作用。
World J Biol Psychiatry. 2012 Jan;13(1):65-74. doi: 10.3109/15622975.2010.543431. Epub 2011 Jan 19.
10
Exploring whether genetic differences between siblings explain sibling differences in criminal justice outcomes.探讨兄弟姐妹之间的遗传差异是否可以解释他们在刑事司法结果上的差异。
Compr Psychiatry. 2014 Jan;55(1):93-103. doi: 10.1016/j.comppsych.2013.06.002. Epub 2013 Jul 12.
本文引用的文献
1
Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention.自闭症高风险兄弟姐妹中的多巴胺能变异：与发起共同注意的关联。
Autism Res. 2016 Nov;9(11):1142-1150. doi: 10.1002/aur.1623. Epub 2016 Mar 15.
2
Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.外化行为中基因-环境相互作用的潜在机制：系统综述与理论机制探寻
Clin Child Fam Psychol Rev. 2015 Dec;18(4):413-42. doi: 10.1007/s10567-015-0196-4.
3
The Dopamine D2 Receptor Polymorphism (DRD2 TaqIA) Interacts with Maternal Parenting in Predicting Early Adolescent Depressive Symptoms: Evidence of Differential Susceptibility and Age Differences.多巴胺 D2 受体多态性（DRD2 TaqIA）与母婴互动共同预测青少年早期抑郁症状：易感性和年龄差异的证据。
J Youth Adolesc. 2015 Jul;44(7):1428-40. doi: 10.1007/s10964-015-0297-x. Epub 2015 May 5.
4
Peer Victimization and DRD4 Genotype Influence Problem Behaviors in Young Children.同伴受欺负情况和多巴胺D4受体基因（DRD4）基因型影响幼儿的问题行为。
J Youth Adolesc. 2015 Aug;44(8):1478-93. doi: 10.1007/s10964-015-0282-4. Epub 2015 Apr 14.
5
Genes in the dopaminergic system and delinquent behaviors across the life course: the role of social controls and risks.多巴胺能系统中的基因与生命历程中的犯罪行为：社会控制与风险的作用
Crim Justice Behav. 2014 Jun;41(6):713-731. doi: 10.1177/0093854813514227.
6
Genetic variants of neurotransmitter-related genes and miRNAs in Egyptian autistic patients.埃及自闭症患者中神经递质相关基因和微小RNA的遗传变异
ScientificWorldJournal. 2013 Dec 23;2013:670621. doi: 10.1155/2013/670621. eCollection 2013.
7
Mothers' prenatal stress and their children's antisocial outcomes--a moderating role for the dopamine D4 receptor (DRD4) gene.母亲产前压力与孩子的反社会行为结果——多巴胺D4受体（DRD4）基因的调节作用
J Child Psychol Psychiatry. 2014 Jan;55(1):69-76. doi: 10.1111/jcpp.12138. Epub 2013 Sep 14.
8
"He who sees things grow from the beginning will have the finest view of them" a systematic review of genetic studies on psychological traits in infancy.“从一开始就看到事物发展的人，将能最好地观察它们”——婴儿期心理特征的遗传学研究的系统综述。
Neurosci Biobehav Rev. 2013 Sep;37(8):1500-17. doi: 10.1016/j.neubiorev.2013.04.013. Epub 2013 May 2.
9
Beyond autism: a baby siblings research consortium study of high-risk children at three years of age.超越自闭症：高危儿童三岁时的婴儿兄弟姐妹研究联盟研究。
J Am Acad Child Adolesc Psychiatry. 2013 Mar;52(3):300-308.e1. doi: 10.1016/j.jaac.2012.12.011. Epub 2013 Feb 8.
10
Behavior and sleep problems in children with a family history of autism.自闭症家族史儿童的行为和睡眠问题。
Autism Res. 2013 Jun;6(3):169-76. doi: 10.1002/aur.1278. Epub 2013 Feb 21.
Zotero 插件