对自闭症谱系障碍高风险兄弟姐妹中常见多巴胺能变异与行为问题的探索。
An exploration of common dopaminergic variants and behavior problems in siblings at high risk for autism spectrum disorder.
作者信息
Gangi Devon N, Usher Lauren V, Messinger Daniel S
机构信息
MIND Institute, University of California, Davis, UC Davis Medical Center, 2825 50(th) Street, Sacramento, CA 95817, USA.
Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Madison, WI 53705, USA.
出版信息
Infant Behav Dev. 2017 Nov;49:267-271. doi: 10.1016/j.infbeh.2017.10.002. Epub 2017 Oct 17.
Abstract
Younger siblings of children with ASD often exhibit elevated internalizing and externalizing problems. We investigated common dopaminergic variants (DRD4 and DRD2) in relation to behavior problems at 36 months. Genotypes linked to less efficient dopaminergic functioning were associated with higher internalizing problems in high-risk siblings.
摘要
患有自闭症谱系障碍（ASD）儿童的年幼兄弟姐妹往往表现出更多的内化和外化问题。我们研究了常见的多巴胺能基因变体（DRD4和DRD2）与36个月大时行为问题的关系。与多巴胺能功能效率较低相关的基因型与高危兄弟姐妹中较高的内化问题有关。
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本文引用的文献
1
Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention.
Autism Res. 2016 Nov;9(11):1142-1150. doi: 10.1002/aur.1623. Epub 2016 Mar 15.
2
Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.
Clin Child Fam Psychol Rev. 2015 Dec;18(4):413-42. doi: 10.1007/s10567-015-0196-4.
3
The Dopamine D2 Receptor Polymorphism (DRD2 TaqIA) Interacts with Maternal Parenting in Predicting Early Adolescent Depressive Symptoms: Evidence of Differential Susceptibility and Age Differences.
J Youth Adolesc. 2015 Jul;44(7):1428-40. doi: 10.1007/s10964-015-0297-x. Epub 2015 May 5.
4
Peer Victimization and DRD4 Genotype Influence Problem Behaviors in Young Children.
J Youth Adolesc. 2015 Aug;44(8):1478-93. doi: 10.1007/s10964-015-0282-4. Epub 2015 Apr 14.
5
Genes in the dopaminergic system and delinquent behaviors across the life course: the role of social controls and risks.
Crim Justice Behav. 2014 Jun;41(6):713-731. doi: 10.1177/0093854813514227.
6
Genetic variants of neurotransmitter-related genes and miRNAs in Egyptian autistic patients.
ScientificWorldJournal. 2013 Dec 23;2013:670621. doi: 10.1155/2013/670621. eCollection 2013.
7
Mothers' prenatal stress and their children's antisocial outcomes--a moderating role for the dopamine D4 receptor (DRD4) gene.
J Child Psychol Psychiatry. 2014 Jan;55(1):69-76. doi: 10.1111/jcpp.12138. Epub 2013 Sep 14.
8
"He who sees things grow from the beginning will have the finest view of them" a systematic review of genetic studies on psychological traits in infancy.
Neurosci Biobehav Rev. 2013 Sep;37(8):1500-17. doi: 10.1016/j.neubiorev.2013.04.013. Epub 2013 May 2.
9
Beyond autism: a baby siblings research consortium study of high-risk children at three years of age.
J Am Acad Child Adolesc Psychiatry. 2013 Mar;52(3):300-308.e1. doi: 10.1016/j.jaac.2012.12.011. Epub 2013 Feb 8.
10
Behavior and sleep problems in children with a family history of autism.
Autism Res. 2013 Jun;6(3):169-76. doi: 10.1002/aur.1278. Epub 2013 Feb 21.
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