Ledda Caterina, Iavicoli Ivo, Bracci Massimo, Avola Roberto, Senia Paola, Santarelli Lory, Pomara Cristoforo, Rapisarda Venerando
Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Occupational Medicine, Department of Public Health, University of Naples Federico II, Naples, Italy.
Toxicol Lett. 2018 Jan 5;282:49-56. doi: 10.1016/j.toxlet.2017.10.014. Epub 2017 Oct 18.
Epidemiologic studies have reported that exposure to arsenic (As) is associated with higher risk of cardiovascular disease (i.e., coronary heart disease and peripheral arterial heart disease) and mortality. This cross-sectional study aimed to compare serum lipid, lipoprotein, and apolipoprotein profiles in workers exposed to As. The subjects of this study included 57 workers exposed to As and 57 controls. Demographic characteristics and occupational information were collected through questionnaires. Exposure to As was assessed in indoor air of a workplace and determined using the creatinine values in the urine. Blood samples were collected using immunochemistry and nephelometry to measure the levels of total cholesterol (CHOL), triglycerides (TRIG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), lipoprotein(a) (Lp(a)), apolipoprotein-A1 (Apo-A1), and apolipoprotein-B (Apo-B). No significant difference in the demographic data was detected between the two groups. Urinary As concentration was significantly (p<0.001) higher in exposed subjects than in the controls (13.4±6.1 and 4.4±6.1μg/gCreat, respectively). No statistically significant differences were observed in CHOL, TRIG, HDL, and LDL concentrations between the two groups. Lp(a), Apo-B, and Apo-B/Apo-A1 ratio values were significantly higher and the Apo-A1 level was significantly lower in the exposed group than in the control subjects. Regression analysis highlighted a significant (p<0.001) association between urinary As and Lp(a), Apo-A1, and Apo-B concentration, and Apo-B/Apo-A1 ratio. This study revealed the influence of As on apolipoproteins, suggesting a potential risk of cardiovascular diseases in subjects exposed to low levels of As.
流行病学研究报告称，接触砷（As）会增加患心血管疾病（即冠心病和外周动脉心脏病）及死亡的风险。这项横断面研究旨在比较接触砷的工人的血清脂质、脂蛋白和载脂蛋白谱。本研究的对象包括57名接触砷的工人和57名对照组人员。通过问卷调查收集人口统计学特征和职业信息。在工作场所的室内空气中评估砷暴露情况，并根据尿液中的肌酐值确定砷暴露水平。使用免疫化学和比浊法采集血样，以测量总胆固醇（CHOL）、甘油三酯（TRIG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、脂蛋白（a）[Lp（a）]、载脂蛋白A1（Apo-A1）和载脂蛋白B（Apo-B）的水平。两组之间在人口统计学数据上未检测到显著差异。接触砷的受试者尿砷浓度显著高于对照组（分别为13.4±6.1和4.4±6.1μg/g肌酐，p<0.001）。两组之间在CHOL、TRIG、HDL和LDL浓度方面未观察到统计学显著差异。接触组的Lp（a）水平、Apo-B水平以及Apo-B/Apo-A1比值显著高于对照组，而Apo-A1水平显著低于对照组。回归分析突出显示尿砷与Lp（a）、Apo-A1和Apo-B浓度以及Apo-B/Apo-A1比值之间存在显著关联（p<0.001）。本研究揭示了砷对载脂蛋白的影响，表明低水平砷暴露人群存在心血管疾病的潜在风险。
