Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Department of Emergency, Fujian Provincial Hospital, Fuzhou, China.
PLoS One. 2024 Aug 15;19(8):e0306573. doi: 10.1371/journal.pone.0306573. eCollection 2024.
There are limited epidemiological investigations of blood metal levels related to hyperlipidemia, and results indicating the association between blood lead (Pb), cadmium (Cd) and selenium (Se), and lipid biomarkers have been conflicting.
We included populations for which NHANES collected complete data. Multivariate logistic regression and subgroup analyses were conducted to ascertain the relationship between blood Pb, Cd, and Se levels and hyperlipidemia. Nonlinear relationships were characterized by smoothed curve fitting and threshold effect analysis.
5429 participants in all, with a mean age of 53.70 ± 16.63 years, were included; 47.1% of the subjects were male, and 3683 (67.8%) of them had hyperlipidemia. After modifying for variables with confounders in a multivariate logistic regression model, we discovered a positive correlation between blood Pb and Se levels and hyperlipidemia (Pb: OR:2.12, 95% CI:1.56-2.88; Se: OR:1.84, 95% CI:1.38-2.45). Gender, age, smoking status, alcohol use status, hypertension, diabetes, and body mass index were not significantly linked with this positive correlation, according to subgroup analysis and interaction test (P for interaction>0.05). Positive correlations between blood Pb, Cd, and Se levels and the risk of hyperlipidemia have been found using smooth curve fitting.
This study demonstrates that higher blood levels of Pb, Cd, and selenium are linked to an increased risk of hyperlipidemia.
与高血脂相关的血液金属水平的流行病学研究有限，并且表明血液铅（Pb）、镉（Cd）和硒（Se）与脂质生物标志物之间存在关联的结果相互矛盾。
我们纳入了 NHANES 收集完整数据的人群。采用多变量逻辑回归和亚组分析来确定血液 Pb、Cd 和 Se 水平与高血脂之间的关系。通过平滑曲线拟合和阈值效应分析来描述非线性关系。
共纳入 5429 名参与者，平均年龄为 53.70±16.63 岁，其中 47.1%为男性，3683 名（67.8%）患有高血脂。在多变量逻辑回归模型中对具有混杂因素的变量进行修正后，我们发现血液 Pb 和 Se 水平与高血脂呈正相关（Pb：OR：2.12，95%CI：1.56-2.88；Se：OR：1.84，95%CI：1.38-2.45）。根据亚组分析和交互检验（P 交互值>0.05），性别、年龄、吸烟状况、饮酒状况、高血压、糖尿病和体重指数与这种正相关没有显著关联。通过平滑曲线拟合发现血液 Pb、Cd 和 Se 水平与高血脂风险之间存在正相关。
本研究表明，血液中 Pb、Cd 和硒水平升高与高血脂风险增加有关。
