Philips Cyriac Abby, Paramaguru Rajaguru, Augustine Philip
Department of Hepatology and Transplant Medicine, PVS Memorial Hospital, Cochin, Kerala, India.
Department of Pathology, PVS Memorial Hospital, Cochin, Kerala, India.
BMJ Case Rep. 2017 Oct 20;2017:bcr-2017-220743. doi: 10.1136/bcr-2017-220743.
A middle-aged man with decompensated cirrhosis and a dimorphic multisite skin rash is diagnosed with rare atypical herpes simplex infection, manifesting Sweet's syndrome (SS) in the absence of other described associations. SS, an acute febrile neutrophilic dermatosis, has three common forms-classical or idiopathic, malignancy associated and drug induced. Systemic autoimmune, connective tissue diseases and infections are also strong associations. The latter is commonly described in Gram-positive bacteria, salmonellosis and Herpes infections are a rare cause of SS, reported only thrice in literature, one with concomitant lupus, the second with associated mycobacterial infection and third, in metastatic breast disease in contrast to our patient. Atypical rash, especially if dimorphic, warrants histopathological evaluation to confirm underlying disease.
一名患有失代偿期肝硬化且出现双形多部位皮疹的中年男子被诊断为罕见的非典型单纯疱疹感染,在无其他所述关联情况时表现为斯威特综合征(SS)。SS是一种急性发热性嗜中性皮病,有三种常见类型——经典型或特发型、与恶性肿瘤相关型和药物诱发型。全身性自身免疫性疾病、结缔组织病和感染也与之密切相关。后者常见于革兰氏阳性菌、沙门氏菌感染,而疱疹感染是SS的罕见病因,文献中仅报道过三例,一例伴有狼疮,第二例伴有分枝杆菌感染,第三例与转移性乳腺癌相关,与我们的患者情况不同。非典型皮疹,尤其是双形皮疹,需要进行组织病理学评估以确诊潜在疾病。