Department of Computer Science, University of Verona, Verona, Italy.
Department of Medicine, University of Verona, Verona, Italy.
J Biophotonics. 2018 Apr;11(4):e201700209. doi: 10.1002/jbio.201700209. Epub 2017 Dec 18.
Radium ( Ra) is widely used in nuclear medicine to treat patients with osseous metastatic prostate cancer. In clinical practice Ra cannot be imaged directly; however, gamma photons produced by its short-lived daughter nuclides can be captured by conventional gamma cameras. In this work, we show that Ra and its short-lived daughter nuclides can be detected with optical imaging techniques. The light emission of Ra was investigated in vitro using different setups in order to clarify the mechanism of light production. The results demonstrate that the luminescence of the Ra chloride solution, usually employed in clinical treatments, is compatible with Cerenkov luminescence having an emission spectrum that is almost indistinguishable from CR one. This study proves that luminescence imaging can be successfully employed to detect Ra in vivo in mice by imaging whole body Ra biodistribution and more precisely its uptake in bones.
镭（Ra）在核医学中被广泛用于治疗患有骨转移前列腺癌的患者。在临床实践中，Ra 不能直接成像；但是，其短寿命子核素产生的伽马光子可以被常规伽马相机捕获。在这项工作中，我们表明可以使用光学成像技术检测 Ra 和其短寿命子核素。为了阐明发光机制，我们使用不同的设置对 Ra 的光发射进行了体外研究。结果表明，Ra 氯化物溶液的发光通常用于临床治疗，与符合契伦科夫辐射的光致发光兼容，其发射光谱几乎与 CR 光致发光相同。这项研究证明，发光成像可以通过成像全身 Ra 生物分布并更准确地成像其在骨骼中的摄取来成功地用于体内检测小鼠中的 Ra。
