University Chemical Laboratories, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 612 65 Brno, Czech Republic.
J Chem Phys. 2017 Oct 21;147(15):152715. doi: 10.1063/1.4997377.
We explore the energy landscape for a four-fold telomere repeat, obtaining interconversion pathways between six experimentally characterised G-quadruplex topologies. The results reveal a multi-funnel system, with a variety of intermediate configurations and misfolded states. This organisation is identified with the intrinsically multi-functional nature of the system, suggesting a new paradigm for the classification of such biomolecules and clarifying issues regarding apparently conflicting experimental results.
我们探索了一个四联体端粒重复的能量景观，获得了六种实验表征的 G-四链体拓扑结构之间的相互转化途径。研究结果揭示了一个多漏斗系统，具有多种中间构象和错误折叠状态。这种组织与系统的固有多功能性质有关，为这类生物分子的分类提出了新的范例，并澄清了关于明显相互矛盾的实验结果的问题。
