Röder Konstantin, Wales David J
Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Front Mol Biosci. 2022 Jan 27;9:820792. doi: 10.3389/fmolb.2022.820792. eCollection 2022.
The energy landscape perspective is outlined with particular reference to biomolecules that perform multiple functions. We associate these multifunctional molecules with multifunnel energy landscapes, illustrated by some selected examples, where understanding the organisation of the landscape has provided new insight into function. Conformational selection and induced fit may provide alternative routes to realisation of multifunctionality, exploiting the possibility of environmental control and distinct binding modes.
本文概述了能量景观观点，特别提及了具有多种功能的生物分子。我们将这些多功能分子与多通道能量景观联系起来，并通过一些选定的例子进行说明，其中对景观组织的理解为功能提供了新的见解。构象选择和诱导契合可能提供实现多功能性的替代途径，利用环境控制和不同结合模式的可能性。
