INNOVENT e. V., Biomaterials Department, Prüssingstrasse 27B, D-07745 Jena, Germany.
Marmara University, Department of Bioengineering, Goztepe Campus, 34722, Istanbul, Turkey.
Int J Biol Macromol. 2018 Feb;107(Pt B):2312-2319. doi: 10.1016/j.ijbiomac.2017.10.120. Epub 2017 Oct 18.
Levan is a high molecular weight fructose-based biotechnologically available polysaccharide with a range of interesting properties qualifying this molecule for applications in biomedicine. In this study, new levan derivatives containing methacrylate groups attached either via ester or urethane linkages to the fructan backbone could be synthesized and structurally characterized by conventional analytical techniques. The photochemical crosslinking of these substances applying different photoinitiator systems and reaction conditions resulted in hydrogels of diverse properties which were investigated with regard to mechanical behaviour, hydrolytic degradability, and cytocompatibility. It was found that crosslinkable levan derivatives represent a new class of promising biopolymer-based macromers broadening the spectrum of available biomaterials to facilitate the adaption to the requirements of specific applications.
低聚糖是一种高分子量的基于果糖的生物技术可得多糖，具有一系列有趣的性质，使该分子有资格应用于生物医学领域。在这项研究中，可以合成含有甲基丙烯酰基的新型低聚糖衍生物，并通过常规分析技术对其结构进行表征。通过不同的光引发剂体系和反应条件，对这些物质进行光化学交联，得到了具有不同性质的水凝胶，并对其机械性能、水解降解性和细胞相容性进行了研究。结果表明，可交联的低聚糖衍生物代表了一类有前途的新型生物聚合物大分子单体，拓宽了可用生物材料的范围，以适应特定应用的要求。
