Wijeyekoon Ruwani, Suriyakumara Vindika, Gamage Ranjanie, Fernando Tharushi, Jayasuriya Amila, Amarasinghe Dhanusha, Gunasekara Harsha, Sirisena Dharshana, Amaratunga Dhammika, Muthukuda Chanaka, Barker Roger A, Williams-Gray Caroline, De Silva Ranil
John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK.
Genetic, Diagnostic and Research Laboratory, Department of Anatomy, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
Int Arch Med. 2017 Sep 15;10. doi: 10.3823/2516.
Associations between certain environmental and lifestyle factors and Parkinson's disease (PD) have been reported in several studies, but information on these factors and Parkinson's Disease (PD) in South Asia, is limited.
To determine associations between lifestyle factors and PD in an urban clinic-based study in Sri Lanka.
In this case-control study, demographic and lifestyle factor data (including diet, coffee/tea drinking, smoking, alcohol status) was collected from an unselected cohort of PD patients and age and gender-matched controls attending clinics in Greater Colombo, Sri Lanka. Associations between lifestyle factors and PD status were assessed using Logistic Regression analysis, while links with age of PD onset were explored with Kaplan Meier and Cox Regression survival analyses. Results with p<0.05 were considered to be statistically significant.
Of 229 patients with parkinsonism, 144 had Idiopathic PD using standard diagnostic criteria. Controls numbered 102. Coffee drinkers and smokers were significantly less likely to have PD (coffee, p<0.001; Odds Ratio (OR)=0.264; smoking, p=0.043; OR=0.394). Coffee drinkers were older at PD onset (p<0.001). Similar trends seen with tea drinking were not statistically significant.
This is the first formal study of PD and these lifestyle factors in South Asia. It demonstrates an inverse association between coffee drinking, smoking and PD, and an association between coffee drinking and later age of PD onset. This is in line with other studies done worldwide, suggesting biological associations with global relevance.
多项研究报告了某些环境和生活方式因素与帕金森病（PD）之间的关联，但关于南亚地区这些因素与帕金森病（PD）的信息有限。
在斯里兰卡一项基于城市诊所的研究中确定生活方式因素与PD之间的关联。
在这项病例对照研究中，从斯里兰卡大科伦坡地区诊所的未经选择的PD患者队列以及年龄和性别匹配的对照中收集人口统计学和生活方式因素数据（包括饮食、咖啡/茶饮用、吸烟、饮酒状况）。使用逻辑回归分析评估生活方式因素与PD状态之间的关联，同时通过Kaplan Meier和Cox回归生存分析探索与PD发病年龄的联系。p<0.05的结果被认为具有统计学意义。
在229例帕金森综合征患者中，根据标准诊断标准，144例患有特发性PD。对照组有102例。喝咖啡者和吸烟者患PD的可能性显著降低（咖啡，p<0.001；优势比（OR）=0.264；吸烟，p=0.043；OR=0.394）。喝咖啡者PD发病时年龄较大（p<0.001）。喝茶的类似趋势无统计学意义。
这是南亚地区关于PD和这些生活方式因素的首次正式研究。它表明喝咖啡、吸烟与PD之间存在负相关，以及喝咖啡与较晚的PD发病年龄之间存在关联。这与全球其他研究一致，表明存在具有全球相关性的生物学关联。
